Table 3. Summary of Pfk13 gene mutations detected in Plasmodium falciparum pretreatment and DF samples, 9 countries in Africa, 2014–2018*.
|
|
No. samples pretreatment (DF) |
|||||
|---|---|---|---|---|---|---|
| Country (year) | Total with sequencing attempted | Poor quality or no amplification | Successfully sequenced | Wild-type samples pretreatment |
Other nonsynonymous mutations | Synonymous mutations |
| Angola (2015) | 379 (0) | 77 (0) | 302 (0) | 291 (0) | 5 (0) | 6 (0) |
| Angola (2017) | 38 (38) | 0 (2) | 38 (36) | 37 (36) | 1 (0) | 0 (0) |
| Benin (2017) | 175 (19) | 20 (1) | 155 (18) | 151 (18) | 1 (0) | 3 (0) |
| DRC (2017–2018) | 317 (316) | 13 (34) | 304 (282) | 295 (269) | 1 (2) | 8 (11) |
| Guinea (2016) | 409 (23) | 20 (1) | 389 (22) | 380 (22) | 1 (0) | 8 (0) |
| Kenya (2016–2017) | 325 (92) | 7 (4) | 318 (88) | 302 (85) | 8 (2) | 8 (1) |
| Malawi (2014) | 8 (19) | 1 (5) | 7 (14) | 7 (14) | 0 (0) | 0 (0) |
| Mali (2015–2016) | 320 (90) | 68 (48) | 252 (42) | 244 (39) | 1 (0) | 7 (3) |
| Tanzania (2016) | 345 (72) | 20 (12) | 325 (60) | 306 (57) | 6 (0) | 13 (3) |
| Zambia (2016) |
263 (0) |
50 (0) |
213 (0) |
200 (0) |
1 (0) |
12 (0) |
| Total | 2,579 (669) | 276 (107) | 2,303 (562) | 2,213 (540) | 25 (4) | 65 (18) |
*DF, day of failure; DRC, Democratic Republic of the Congo; Pfk13, Plasmodium falciparum kelch 13.