Table 4. Summary of Pfk13 nonsynonymous mutations detected in Plasmodium falciparum pretreatment and DF samples, 9 countries in Africa, 2014–2018*.
| Mutation | Country | Codon change | No. samples pretreatment (DF) | Country or region where previously reported (reference) |
|---|---|---|---|---|
| I416V | Tanzania | ATA → GTA | 1 (0) | Tanzania (14) |
| P419S | Guinea | CCA → TCA | 1 (0) | NA |
| E433D | Tanzania | GAA → GAC | 1 (0) | Tanzania (14) |
| R471S | Tanzania | CGT → AGT | 1 (0) | Tanzania (14) |
| S477Y | DRC | TCT → TAT | 0 (1) | Grande Comore Island (16) |
| A504V | Angola (2017) | GCT → GTT | 1 (0) | Gabon (17) |
| S522C | Kenya | AGT → TGT | 2 (0) | Africa (18) |
| A569G | Benin | GCA → GGA | 1 (0) | Gambia (19) and Niger (20) |
| A578S | Angola (2015) | GCT → TCT | 4 (0) | Africa (19) |
| A578S | DRC | GCT → TCT | 1 (1) | Africa (19) |
| A578S | Mali | GCT → TCT | 1 (0) | Africa (19) |
| A578S | Kenya | GCT → TCT | 6 (2) | Africa (19) |
| A578S | Tanzania | GCT → TCT | 1 (0) | Africa (19) |
| A578S | Zambia | GCT → TCT | 1 (0) | Africa (19) |
| Q613R | Angola (2015) | CAA → CGA | 1 (0) | NA |
| Q613E |
Tanzania |
CAA → GAA |
2 (0) |
Tanzania (14) |
| Total | 25 (4) |
*DF, day of failure; DRC, Democratic Republic of the Congo; NA, not available; Pfk13, Plasmodium falciparum kelch 13.