Table 3. Response to first round of triclabendazole treatment for Fasciola hepatica infection among preschool and school-age children compared with failure to respond to first or fourth round of treatment, Cusco, Peru*.
| Characteristic | Cured after first round, n = 80 | Failed after first round, n = 66 | p value† | Failed after fourth round, n = 17 | p value† |
|---|---|---|---|---|---|
| District | |||||
| Anta | 27 (34) | 26 (39) | 0.48 | 12 (71) | 0.005 |
| Other |
53 (64) |
40 (61) |
|
5 (29) |
|
| Fas2 ELISA result | |||||
| Negative | 27 (35) | 12 (18) | 0.02 | 2 (12) | 0.08 |
| Positive |
50 (65) |
54 (82) |
|
15 (88) |
|
| Likelihood of poverty‡ | |||||
| <50% | 56 (70) | 56 (89) | 0.08 | 17 (100) | 0.03 |
| >50% |
16 (30) |
7 (11) |
|
0 (0) |
|
| Other parasites§ | |||||
| No | 42 (53) | 41 (62) | 0.24 | 11 (65) | 0.35 |
| Yes |
38 (48) |
25 (38) |
|
6 (35) |
|
| Sex | |||||
| F | 44 (55) | 33 (50) | 0.54 | 10 (59) | 0.77 |
| M |
36 (45) |
33 (50) |
|
7 (41) |
|
| Age, y, mean ± SD |
10.5 ± 2.9 |
10.4 ± 3.4 |
0.85 |
9.0 ± 3.6 |
0.06 |
| Baseline egg count, eggs/g of stool | 33.3 (6.6–53.3) | 48.3 (25–87.5) | 0.001 | 60 (26–100) | 0.005 |
| Baseline hemoglobin, g/dL¶ | 12.9 (12.1–13.7) | 12.9 (12.3–13.4) | 0.97 | 12.3 (12–13) | 0.08 |
| Baseline HAZ# | −1.6 (−2.2 to −1.0)# | −1.5 (−2.0 to −0.9)# | 0.19 | −1.2 (−1.9 to −0.7) | 0.17 |
| Eosinophil count, cells/μL | 300 (190–460)# | 265 (197–412) | 0.36 | 310 (230–500) | 0.64 |
*Values are no. (%) or median (interquartile range) except as indicated. HAZ, height-for-age Z score. †By Mann-Whitney U test. ‡Likelihood of living under US $3.75/day poverty line (18). §Gastrointestinal parasites. ¶Uncorrected at enrollment. #One or 2 persons were missing information for this variable.