Table 4. Clinical characteristics of 17 children who failed 4 rounds of triclabendazole treatment for Fasciola hepatica infection among preschool and school-age children, Cusco, Peru*.
Child | Community | District | Age, y/sex | Other parasites | HAZ | Living under US $3.75/day | ERR, %† | Total drug dose, mg/kg‡ | Additional treatment received |
---|---|---|---|---|---|---|---|---|---|
1 | Anta | Anta | 6.8/F | Yes | −0.6 | 25 | 0§ | 90 | 1 more round |
2 | Anta | Anta | 14.1/M | No | −2.3 | 25 | 40 | 90 | 2 more rounds |
3 | Conchacalla | Anta | 10.5/M | No | −1.8 | 13 | 67 | 210 | Nitazoxanide |
4 | Conchacalla | Anta | 3.2/F | No | −2.4 | 36 | 40 | 50 | 2 more rounds |
5 | Conchacalla | Anta | 6.0/F | No | −0.4 | 36 | 0§ | 210 | None |
6 | Inquilpata | Anta | 8.5/M | No | −0.9 | 36 | 30 | 50 | 2 more rounds |
7 | Inquilpata | Anta | 9.7/F | No | −1.2 | 36 | 43 | 50 | 2 more rounds |
8 | Inquilpata | Anta | 3.3/M | Yes | −1.2 | 49 | +275 | 210 | None |
9 | Izcuchaca | Anta | 13.9/F | No | −0.6 | 36 | +574 | 150 | 1 more round |
10 | Izcuchaca | Anta | 7.4/M | No | −0.6 | 25 | 63 | 150 | 1 more round |
11 | Mantoclla | Anta | 7.3/F | Yes | −2.0 | 25 | 10 | 150 | None |
12 | Mantoclla | Anta | 9.2/F | Yes | −1.9 | 25 | 31 | 150 | None |
13 | Caccahuara | Ancahuasi | 13.1/F | No | −1.5 | 25 | 17 | 210 | Nitazoxanide |
14 | Caccahuara | Ancahuasi | 15.5/F | No | −1.9 | 13 | +50 | 210 | None |
15 | Caccahuara | Ancahuasi | 7.8/M | No | −1.1 | 25 | +100 | 210 | Nitazoxanide |
16 | Chaquillccasa | Ancahuasi | 11.5/M | Yes | −0.9 | 25 | +250 | 210 | None |
17 | Chaquillccasa | Ancahuasi | 5.5/F | Yes | −2.1 | 49 | 63 | 210 | 1 more round |
*ERR, egg reduction rate; HAZ, height-for-age Z score. †Between baseline and after the fourth round of treatment, as estimated by the number of eggs in Kato Katz tests. + signs indicate the percent increase in the egg count. ‡Total cumulative dose received after the fourth round of treatment §Diagnosed only by Lumbreras rapid sedimentation test and a negative Kato Katz test result.