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. 2021 Jun 24;12(1):1508–1526. doi: 10.1080/21505594.2021.1932183

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Linkage analysis of the transmission stage production in S. mansoni parasites and QTLs interactions. (a) Linkage analysis of average cercarial production phenotype in combined crosses A and B demonstrated that transmission stage production is a polygenic trait controlled by three major QTLs with statistically significant LOD: on chr. 1 (LOD = 5.63), on chr. 2 (LOD = 8.16) and on chr. 5 (LOD = 6.37). The blue dotted line represents the 1,000 permutation threshold. (b) Genetic architecture of cercarial production is influenced by the shedding week (first shedding week corresponds to week 4 post-infection), demonstrating a sequential pattern of QTL emergence involved in transmission stage production (see also Supplementary Figure 4)