Table 4.

Summary table of the 3 top candidate genes for each locus involved in cercarial production in the parasite S. mansoni based on the computed genoscore CDS (see Materials & Methods) and their relative positions to the maximum peak. NA: gene not captured by the S. mansoni baits (exome capture). In bold: selected best candidate genes based on their annotations (GFF or HHsearch)

Chromosome	Gene ID	GFF annotation	HHsearch annotation	Max. LOD	Genoscore
chr. 1	Smp_152850	Tetratricopeptide-like helical domain superfamily	Putative 70 kda peptidylprolyl isomerase PFL2275c	5.63	1.646
	Smp_057230	Aminoacyl-tRNA synthetase, class II	Seryl-tRNA synthetase (SerRS)	NA	1.286
	Smp_246820	No annotation available	hypothetical protein TTHA1254	4.05	1.114
chr. 2	Smp_347740	Coiled-coil domain-containing protein 39	Nucleoporin_FG2	3.86	7.657
	Smp_328700	No annotation available	Engineered transmembrane domain variant	NA	2.153
	Smp_170430	FAD dependent oxidoreductase	D-aminoacid oxidase, N-terminal domain	2.81	1.491
chr. 3	Smp_343200	Pleckstrin homology domain	G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1)	8.16	1.653
	Smp_190770	Lanthionine synthetase C-like	Nisin biosynthesis protein NisC	5.41	1.426
	Smp_138060	No annotation available	Cationic trypsin (e.c.3.4.21.4)	7.66	1.227
chr. 4	Smp_313330	No annotation available	No annotation available	3.35	1.732
	Smp_150840	Zinc finger, C2H2, LYAR-type	60S ribosomal protein L8, 60S	2.47	1.502
	Smp_334250	Epithelial sodium channel	Acid-sensing ion channel 1	3.42	1.257
chr. 5	Smp_330680	No annotation available	No annotation available	NA	6.997
	Smp_330700	No annotation available	No annotation available	NA	3.784
	Smp_330760	IQ motif, EF-hand binding site	Calmodulin, IQ domain-containing protein G	4.50	3.631