Table I.
Study characteristics of discovery and replication cohorts in whole blood DNA methylation analyses
| Cohorta | Country | Age group | Number | Age, years (mean(SD)) | N(%) Male | N(%) allergy (questionnaire + aeroallergen sIgE) | Design |
|---|---|---|---|---|---|---|---|
| BAMSE | Sweden | Pre-school age | 247 | 4.26(0.20) | 134(54.3%) | 117(47.4%) | Discovery |
| INMA-SAB | Spain | 166 | 4.35(0.23) | 84(50.6%) | 38(22.9%) | ||
| PIAMA | The Netherlands | 223 | 4.08(0.21) | 119(53.4%) | 64(28.7%) | ||
| BAMSE | Sweden | School age | 235 | 8.32(0.41) | 125(53.2%) | 96(40.9%) | |
| BAMSE-epi | Sweden | 383 | 8.30(0.52) | 207(54.0%) | 75(19.6%) | ||
| PIAMA | The Netherlands | 203 | 8.06(0.28) | 101(49.8%) | 57(28.1%) | ||
| EDEN | France | Pre-school age | 143 | 5.65(0.10) | 87(60.8%) | 22(15.4%) | Replication |
| BIB | United Kingdom | 514 | 4.53(0.36) | 278(54.1%) | NA | ||
| INMA-GIP | Spain | 74 | 4 | 36(48.6%) | NA | ||
| Rhea | Greece | 490 | 4.26(0.27) | 254(51.8%) | NA | ||
| ECA | Norway | School age | 213 | 10.89(0.78) | 112(52.6%) | 35(16.4%) | |
| INMA-VAL | Spain | 58 | 7.50(0.20) | 31(53.4%) | NA | ||
| PIAMA | The Netherlands | 361 | 8.30(0.46) | 193(53.5%) | 46 (12.7%) | ||
| Robbic-Bologna | Italy | 123 | 7.82(0.51) | 63(51.2%) | NA | ||
| Robbic-Rome | Italy | 214 | 8.73(0.27) | 108(50.5%) | NA | ||
| Karelia | Finland | Adolescent age | 98 | 15.74(1.59) | 38 (38.8%) | 35(35.7%) | |
| INMA-MEN | Spain | 75 | 14 | 35(46.7%) | 14(18.7%) | ||
| PIAMA | The Netherlands | 546 | 16.35(0.22) | 271(49.6%) | 115(21.1%) |