Table III.
Independent meta-analysis of the association of DNA methylation at 21 replicated CpG sites with allergic disease defined on the basis of symptoms without considering IgE levels in 8 replication cohorts
| CpG site | Gene namec | Meta-analysis coef | Meta-analysis P value | Direction |
|---|---|---|---|---|
| cg11699125 | GPR153, ACOT7 | −0.0189 | 1.78E-09 | ----+----+-+ |
| cg15344640 | MXD3, LMAN2 | −0.0064 | 2.95E-04 | --+-++---+-- |
| cg23642826 | ZBTB48, KLHL21 | −0.0079 | 8.06E-07 | ----++------ |
| cg21932513 | RCC2, PADI4 | −0.0093 | 8.26E-07 | ----+++--+-- |
| cg11725101 | NBPF16 | −0.0074 | 5.28E-05 | ----?+-+-+-+ |
| cg06528816 | TTC7A, CALM2 | −0.0111 | 3.51E-08 | ----+----?-- |
| cg05736642 | RGS12, HTT | −0.0069 | 4.73E-05 | ----++------ |
| cg16673806 | REEP2 | −0.0064 | 3.43E-05 | ----++---+-- |
| cg08969102 | PPP2CA | −0.0089 | 2.73E-06 | ----?+------ |
| cg12077460 | ERI1,CLDN23 | −0.0117 | 1.90E-06 | ----++---+-- |
| cg13576859 | FBP1 | −0.0083 | 1.88E-08 | ----++---+-- |
| cg13458609 | ENG, FPGS | −0.0122 | 5.63E-08 | --+-?+------ |
| cg06597413 | CCND1, TPCN2 | −0.0084 | 1.71E-09 | ----+----+-- |
| cg21498475 | SLC24A6, TPCN1 | −0.0088 | 1.48E-07 | --+------?-+ |
| cg13645296 | HERC1, DAPK2 | −0.0172 | 2.78E-12 | ---------?-- |
| cg26235490 | ABR, TIMM22 | −0.0097 | 3.17E-09 | -----+---+-- |
| cg01330991 | KDM6B, DNAH2 | −0.008 | 3.28E-08 | ----++---+-- |
| cg09981841 | EPN2, B9D1 | −0.0075 | 7.01E-05 | --+-++------ |
| cg00170714 | PSMC3IP, MLX | −0.007 | 1.74E-04 | ----?+-----+ |
| cg06483820 | MSI2, AKAP1 | −0.0086 | 1.01E-09 | ----+------- |
| cg22503106 | METRNL | −0.0108 | 8.34E-07 | ----++---+-- |
Coef: Regression coefficient from meta-analysis; P value:
P value from meta-analysis of the replication cohorts only, without considering the discovery population.
For each cohort participating in the analysis, “+” indicates a positive direction of effect, “-” indicates a negative direction of effect, and “?” indicates missing information for that CpG in a given cohort. Cohort order is as follows: BIB, Rhea, INMA (GIP), EDEN, INMA (VAL), PIAMA (age 8), Robbic (Rome), Robbic (Bologna), ECA, INMA (MEN), PIAMA (age 16), Karelia.