Table 2. . CYP2B6 genetic associations with methadone-induced nausea and vomiting, adjusted for covariates including weight, race, age, surgery type and sex.
| SNP | Referent allele (frequency) | Minor allele (frequency) | Referent group | Alternative group | Unadjusted analysis | Covariate adjusted analysis | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Rate ratio | p-value | 95% CI | Rate ratio | p-value | 95% CI | |||||
| Dominant model | ||||||||||
| rs2279343 | A (0.94) | G (0.06) | AA | AG/GG | 2.68 | 0.025 | 1.14–6.35 | 2.50 | 0.092 | 0.86–7.22 |
| Additive model | ||||||||||
| rs2279343 | A (0.94) | G (0.06) | AA | AG | 2.68 | 0.025 | 1.14–6.35 | 2.50 | 0.092 | 0.86–7.22 |
| GG | NA | NA | NA | NA | NA | NA | ||||
| rs1038376 | A (0.71) | T (0.29) | AA/AT | AT | 0.79 | 0.622 | 0.31–2.03 | 1.33 | 0.612 | 0.44–4.00 |
| TT | 4.26 | 0.001 | 1.76–10.27 | 3.56 | 0.011 | 1.33–9.55 | ||||
| Recessive model | ||||||||||
| rs1038376 | A (0.71) | T (0.29) | AA/AT | TT | 4.7 | 0.00015 | 2.11–10.46 | 3.21 | 0.01 | 1.32–7.79 |
NA: Not applicable.