Table 3.

Direct, indirect, and total effects of medications as a mediator in the relationship between SIRS and coma

	Estimate	Lower bound	Upper bound
Paralytic medication as mediator
Controlled direct effect	1.51	1.22	1.79
Natural direct effect	1.51	1.22	1.79
Natural indirect effect	0.78	0.64	0.91
Total effect	2.29	2.01	2.56
Proportion mediated	0.60	0.58	0.62
Sedative medication as mediator
Controlled direct effect	0.71	0.61	0.82
Natural direct effect	0.71	0.61	0.82
Natural indirect effect	0.48	0.41	0.55
Total effect	1.19	1.07	1.32
Proportion mediated	0.55	0.54	0.56
Combined paralytic, sedative, and/or opiate as mediator
Controlled direct effect	0.51	0.42	0.60
Natural direct effect	0.51	0.42	0.60
Natural indirect effect	0.41	0.35	0.46
Total effect	0.92	0.82	1.0
Proportion mediated	0.56	0.55	0.57