1. Draft summary of findings table.
| Statins compared with placebo (or usual care or any control intervention) for the primary prevention of venous thromboembolism | ||||||
|
Patient or population: participants without VTEa Settings: hospital, outpatients or community Intervention: statin (any) Comparison: placebo (or usual care or any control intervention) | ||||||
| Outcomes | Anticipated absolute effects * | Relative effect (95% CI) | No of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with placebo | Risk with statin | |||||
|
VTE (follow‐up) |
Low risk population | OR (value) ((value) to (value)) | (value) ((value)) | (Delete as
appropriate) ⊕⊝⊝⊝ very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
||
| (value) per 1000 | (value) per 1000 ((value) to (value)) | |||||
| Medium risk population | ||||||
| (value) per 1000 | (value) per 1000 ((value) to (value)) | |||||
| High risk population | ||||||
| (value) per 1000 | (value) per 1000 ((value) to (value)) | |||||
|
DVT (follow‐up) |
Study population | OR (value) ((value) to (value)) | (value) ((value)) | (Delete as
appropriate) ⊕⊝⊝⊝ very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
||
| (value) per 1000 | (value) per 1000 ((value) to (value)) | |||||
|
PE (follow‐up) |
Study population | OR (value) ((value) to (value)) | (value) ((value)) | (Delete as
appropriate) ⊕⊝⊝⊝ very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
||
| (value) per 1000 | (value) per 1000 ((value) to (value)) | |||||
|
SAE (follow‐up) |
Study population | OR (value) ((value) to (value)) | (value) ((value)) | (Delete as
appropriate) ⊕⊝⊝⊝ very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
||
| (value) per 1000 | (value) per 1000 ((value) to (value)) | |||||
|
Mortality (follow‐up) |
Study population | OR (value) ((value) to (value)) | (value) ((value)) | (Delete as
appropriate) ⊕⊝⊝⊝ very low ⊕⊕⊝⊝ low ⊕⊕⊕⊝ moderate ⊕⊕⊕⊕ high |
||
| (value) per 1000 | (value) per 1000 ((value) to [value)) | |||||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; DVT: deep vein thrombosis; OR: odds ratio; PE: pulmonary embolism; SAE: serious adverse events; VTE: venous thromboembolism | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: we are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: we have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
a Participants are healthy people, or with diseases other than VTE.