Table 2.
KEGG Pathway identifiers of selected metabolites measured following low- and high-dose GLP1 infusion in late-fasted northern elephant seal pups
| Metabolite | Metabolite Type | Metabolite Pathway |
|---|---|---|
| 2-Hydroxyglutaric acid | Glutarates | Butanoate metabolism; C5-Branched dibasic acid metabolism |
| 2-Hydroxy-2-methylbutanoic acid | Butyrates | Lipid metabolisma |
| 2-Ketoisocaproic acid | Keto acids | Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Glucosinolate biosynthesis |
| Acetoacetate | Keto acid | Synthesis and degradation of ketone bodies; Valine, leucine and isoleucine degradation; Lysine degradation; Tyrosine metabolism; Propanoate metabolism; Butanoate metabolism |
| Aconitic acid | Tricarboxylic acid | Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; C5-Branched dibasic acid metabolism |
| Adenosine-5-monophosphate | Adenine nucleotide | Purine metabolism |
| α-Aminoadipic acid | Dicarboxylic acids | Lysine biosynthesis; Lysine degradation |
| α-Ketoglutarate | Glutarate | Citrate cycle (TCA cycle); Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Lysine biosynthesis; Lysine degradation; Histidine metabolism; Taurine and hypotaurine metabolism; d-Glutamine and d-glutamate metabolism; Glyoxylate and dicarboxylate metabolism; Butanoate metabolism; C5-Branched dibasic acid metabolism |
| Aminomalonate | Dicarboxylic acid | Amino acid metabolism |
| Aspartic acid | Amino acid | Amino acid metabolism |
| Benzoic acid | Carbocyclic acid | Phenylalanine metabolism; Benzoate degradation; Dioxin degradation; Toluene degradation; Aminobenzoate degradation |
| Cholesterol | Cholestenes | Steroid biosynthesis; Primary bile acid biosynthesis; Steroid hormone biosynthesis; Steroid degradation; Biosynthesis of alkaloids derived from terpenoid and polyketide |
| Citric acid | Tricarboxylic acid | Citrate cycle (TCA cycle); Alanine, aspartate and glutamate metabolism; Glyoxylate and dicarboxylate metabolism |
| Creatinine | Imidazole | Arginine and proline metabolism |
| Cystathionine | Amino acid | Amino acid metabolism |
| Cytosine | Pyrimidinones | Pyrimidine metabolism |
| Erythritol | Sugar alcohol | Sugar alcohol metabolisma |
| Glucose | Hexose | Glycolysis/Gluconeogenesis; Pentose phosphate pathway |
| Glutamic acid | Amino acid | Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Arginine and proline metabolism; Histidine metabolism; Taurine and hypotaurine metabolism; d-Glutamine and d-glutamate metabolism; Glutathione metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Glyoxylate and dicarboxylate metabolism; Butanoate metabolism; C5-Branched dibasic acid metabolism; Nitrogen metabolism |
| Glutamine | Amino acid | Arginine biosynthesis; Purine metabolism; Pyrimidine metabolism; Alanine, aspartate and glutamate metabolism; d-Glutamine and d-glutamate metabolism; Glyoxylate and dicarboxylate metabolism; Vitamin B6 metabolism; Nitrogen metabolism; Aminoacyl-tRNA biosynthesis |
| Glyceric acid | Sugar acids | Pentose phosphate pathway; Glycine, serine and threonine metabolism; Glycerolipid metabolism; Glyoxylate and dicarboxylate metabolism; Methane metabolism |
| Hexitol | Sugar alcohols | Fructose and mannose metabolism |
| Hydroxybutyric acid | Hydroxybutyrate | Synthesis and degradation of ketone bodies; Butanoate metabolism |
| Isocitric acid | Tricarboxylic acid | Citrate cycle (TCA cycle) |
| Isoleucine | Amino acid | Amino acid metabolism |
| Isothreonic acid | Butyrate | Ascorbate and aldarate metabolisma |
| Lactamide | Amide | Cryoprotectanta |
| Lyxitol | Sugar alcohol | Sugar alcohol metabolisma; Pentose and glucuronate interconversions |
| Malic acid | Dicarboxylic acid | Citrate cycle (TCA cycle); Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Methane metabolism |
| Maltose | Disaccharides | Starch and sucrose metabolism |
| Myo-inositol | Sugar alcohol | Galactose metabolism; Ascorbate and aldarate metabolism; Inositol phosphate metabolism |
| N-ε-trimethy-l-lysine | Amines | Carnitine synthesisa |
| Nicotinic acid | Nicotinic acids | Nicotinate and nicotinamide metabolism; Tropane, piperidine and pyridine alkaloid biosynthesis; Biosynthesis of plant secondary metabolites; Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid |
| Octadecanol | Fatty alcohol | Lipid metabolisma |
| Phenylacetic acid | Carbocyclic acid | Phenylalanine metabolism |
| Phosphoenolpyruvate | Hydroxy acid | Glycolysis/Gluconeogenesis; Citrate cycle (TCA cycle); Phenylalanine, tyrosine and tryptophan biosynthesis; Phosphonate and phosphinate metabolism; Pyruvate metabolism; Methane metabolism |
| Succinic acid | Dicarboxylic acid | Citrate cycle (TCA cycle); Oxidative phosphorylation; Alanine, aspartate and glutamate metabolism; Lysine degradation; Tyrosine metabolism; Phenylalanine metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Butanoate metabolism |
| Threitol | Sugar alcohol | Sugar alcohol metabolisma |
| Tyrosine | Amino acid | Ubiquinone and other terpenoid-quinone biosynthesis; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Cyanoamino acid metabolism; Methane metabolism; Thiamine metabolism |
| Uric acid | Xanthine | Purine metabolism |
| Xylitol | Sugar alcohol | Sugar alcohol metabolisma; Pentose and glucuronate interconversions |
| Xylose | Monosaccharide | Carbohydrate metabolism |
TCA, tricarboxylic acid.
a
Obtained from literature, not KEGG pathway identifiers.