Table 3.
Chemical similarity enrichment analysis results of significant clusters of metabolites measured following high-dose GLP1 infusion (compared to control) in late-fasted northern elephant seal pups
| Cluster Name | Cluster Size | P Value (KS) | FDR Adjusted P Value (KS) | No. of Altered Metabolites in Cluster | Metabolites | P-Value Adjusted for Time 0 (HDG vs. Control) | Fold Change of Means (HDG/Control) |
|---|---|---|---|---|---|---|---|
| Sugar alcohols | 9 | 0.0006 | 0.0066 | Higher: 5,No change: 4 | Erythritol | 0.016 | 1.5 |
| Lyxitol | 0.032 | 1.3 | |||||
| Myo-inositol | 0.016 | 1.1 | |||||
| Threitol | 0.016 | 1.4 | |||||
| Xylitol | 0.032 | 1.5 | |||||
| Tricarboxylic acids | 3 | 0.00017 | 0.0038 | Higher: 2,No change: 1 | Aconitic acid | 0.0011 | 1.6 |
| Citric acid | 0.0075 | 1.3 | |||||
| Glutarates | 3 | 0.016 | 0.12 | Higher: 2,No change: 1 | 2-Hydroxyglutaric acid | 0.017 | 1.6 |
| α-Ketoglutarate | 0.021 | 1.7 | |||||
| Hydroxybutyrates | 5 | 0.045 | 0.24 | Lower: 2,No change: 3 | 3-Hydroxybutyric acid | 0.0075 | 0.59 |
| 2-Hydroxyvaleric acid | 0.03 | 0.82 |
HDG, high-dose GLP-1 + glucose; KS, Kolmogorov–Smirnov test. HDG, n = 4 seal pups; control, n = 5 seal pups.