Figure 2.

Effects of chronic fourth ventricular (4V) oxytocin (OT) infusions on body weight, body weight gain, body composition, and energy intake in male chow-fed and diet-induced obese (DIO) mice. Ad libitum-fed mice were either maintained on high-fat diet (HFD) (60% kcal from fat; n = 9–11/group) or chow (n = 9–10/group) for approximately 5 mo before receiving continuous infusions of vehicle or OT (16 nmol/day). A and E: change in body weight in HFD-fed DIO or chow-fed control animals; B and F: change in body weight gain in HFD-fed DIO or chow-fed control animals; C and G: fat mass and lean mass in HFD-fed DIO or chow-fed control animals; D and H: daily energy intake (kcal/day) in HFD-fed DIO or chow-fed control animals. One-way ANOVA; data are expressed as means ± SE. *P < 0.05 OT vs. vehicle or baseline (pretreatment; A and E).