Table 3. Sensitivity analysis for ADHD.
| GsensXY | GsensY | GsensX | |||
|---|---|---|---|---|---|
| Best Fitting PS3 | Unconstrained | Residual1 | -0.106 (-0.135;-0.076) | -0.117 (-0.145;-0.089) | -0.107 (-0.137;-0.077) |
| G confound2 | -0.018 (-0.027;-0.009) | -0.007 (-0.010;-0.004) | -0.017 (-0.026;-0.008) | ||
| Constrained | Residual | -0.106 (-0.135;-0.076) | -0.117 (-0.145;-0.089) | -0.107 (-0.136;-0.077) | |
| G confound | -0.018 (-0.027;-0.009) | -0.007 (-0.010;-0.004) | -0.017 (-0.026;-0.008) | ||
| SNP heritability | Unconstrained | Residual | -0.063 (-0.158;0.031) | -0.01 (-0.074;0.054) | -0.108 (-0.138;-0.079) |
| G confound | -0.061 (-0.153;0.032) | -0.114 (-0.173;-0.055) | -0.016 (-0.024;-0.008) | ||
| Constrained | Residual | -0.052 (-0.096;-0.008) | -0.01 (-0.074;0.054) | -0.107 (-0.136;-0.077) | |
| G confound | -0.078 (-0.113;-0.043) | -0.114 (-0.173;-0.055) | -0.016 (-0.025;-0.008) | ||
| Twin heritability | Unconstrained | Residual | - | - | -0.089 (-0.123;-0.055) |
| G confound | - | - | -0.035 (-0.053;-0.017) | ||
| Constrained | Residual | 0 (0;0) | 0 (0;0) | -0.089 (-0.123;-0.055) | |
| G confound | -0.129 (-0.158;-0.1) | -0.127 (-0.156;-0.099) | -0.035 (-0.053;-0.017) |
Note. Estimates and 95% CI are provided for each scenario.
1Residual association after adjusting for genetic confounding.
2Genetic Confounding.
3Polygenic Score.