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(A) The kinases AKT and SGK1 phosphorylate KMT2D to reduce its methyltransferase activity. (B) miRNAs (e.g., miR-217) targets KMT2D mRNA to reduce KMT2D expression. (C) KMT2D expression is repressed by DNA CpG methylation. (D) The E3 ligase FBXW7 targets KMT2D for protein degradation.
