Table 4.
Multivariable Cox proportional hazards analyses of time-updated VE measures associated with mortality and sorted by lowest to highest AIC score, the HIV Outpatient Study, 1995–2016 (N = 1645).
| Most recent log10 viral load | Viremia log10 copy-years | Proportion attributable time spend at viral load: >50 copies/mL | Proportion attributable time spent at viral load: >200 copies/mL | Model fit index: AIC score (lower = better)∗ | |
| aHR (95% CI) | aHR (95% CI) | aHR (95% CI) | aHR (95% CI) | ||
| Model 1 | 1.30 (1.07–1.58) | 1.15 (1.07–1.23) | 1350 | ||
| Model 2 | 1.21 (0.96–1.52) | 1.17 (1.08–1.26) | 1355 | ||
| Model 3 | 1.22 (1.15–1.28) | 1355 | |||
| Model 4 | 1.40 (1.20–1.64) | 1.43 (1.20–1.72) | 1357 | ||
| Model 5 | 1.44 (1.21–1.72) | 1.10 (1.03–1.18) | 1357 | ||
| Model 6 | 1.39 (1.13–1.71) | 1.11 (1.03–1.19) | 1363 | ||
| Model 7 | 1.19 (1.12–1.25) | 1370 | |||
| Model 8 | 1.67 (1.46–1.90) | 1370 | |||
| Model 9 | 1.70 (1.45–1.99) | 1371 |
∗
Each model included factors listed and adjusted for baseline factors: age, public insurance, HIV risk activity, and pre-cART CD4+ cell count.
aHR = adjusted hazard ratio, AIC = Akaike's information criterion, CI = confidence interval, HR = hazard ratio, PWID = persons who inject drugs, VE = viral exposure.