Table 2.
A compilation of different published studies and reports regarding the photo-inactivation of coronaviruses using UVC irradiation.
| Order | UVC exposure wavelength | UVC light intensity/irradiance | Distance from UVC source/illumination | Inactivation time/conditions | Sample/media | Reference |
|---|---|---|---|---|---|---|
| (a) SARS CoV-1 | ||||||
| 1. | 260 nm | 90 μW cm−2 | 80 cm | 60 min | Vero-E6 cells | Dong, 2003 |
| 2. | 254 nm | 4016 μW cm−2 | 3 cm | 15 min | Vero-E6 cells | Darnell et al., 2004 |
| 3. | 254 nm | 4016 μW cm−2 | 3 cm | 40 min | Non-cellular blood products PBS solution, BSA protein solutions | Darnell and Taylor, 2006 |
| 4. | 254 nm | 200 mJ cm−2 | – | Log reduction factor of ≥3.1 | Platelets concentrates/ plasma | Eickmann et al., 2020 |
| 5. | 222 nm | 3 mJ cm−2 | 22 cm | 25 min (99.9% inactivation) | Aerosols | Buonanno et al., 2020 |
| (b) MERS CoV | ||||||
| 6. | 254 nm | – | 1.22 m | 5 min | Platelets concentrates/ plasma | Bedell et al., 2016 |
| 7. | 254 nm | 200 mJ cm−2 | – | Log reduction factor of ≥3.7 | Platelets concentrates/ plasma | Eickmann et al., 2018 |
| (c) SARS CoV-2 | ||||||
| 8. | 265 nm | 6.2 J/m2 | 75 × 45 × 50 cm UVC chamber | log reduction of ≥3.4 | Platelets concentrates/ plasma | Keil et al., 2020 |
| 9. | 280 ± 5 nm | 3.75 mW cm−2 | 2 cm | 1–60 s | Aerosols | Inagaki et al., 2020 |
| 10. | 254 nm | 70 mJ cm−2 (estimated) | – | 1 log inactivation (estimated) | Aerosols | Sagripanti and Lytle, 2020 |
| 11. | 254 nm | 3.7 mJ cm−2 | – | 3 log inactivation for low virus concentration. | Vero-E6 cells | Bianco et al., 2020 |
| 12. | 254 nm | 1940 mW cm−2 | 3 cm | Complete inactivation in 9 min | Liquid suspension | (Heilingloh et al., 2020) |
| 13. | 222 nm | 0.1 mW cm−2 | 24 cm | 2.51 log reduction (Undetectable levels) in 30 s | Liquid suspension | (Kitagawa et al., 2021) |
| 14. | 254 nm | 2.2 mW cm−2 | 30 cm | Inactivation, by lethal dose (viral inactivation 99.999%) | Liquid suspension | (Sabino et al., 2020) |
| 15. | PX-UV robot model PXUV4D | – | 1 m | 99.992% reduction in 5 min | Liquid suspension and dried samples | (Simmons et al., 2021) |
| 16. | 254 nm | 1.082 mW cm−2 | – | more than 3-log inactivation and inhibition of SARS CoV-2 replication | Vero-E6 cells | (Biasin et al., 2021) |