FIGURE 5.

Multiparametric MRI maps of a representative rat bearing C6 tumor model. (A) T₂-weighted image, (B) T₁ map, (C) T₂ map, (D) ADC map, (E) CEST imaging at 3.5 ppm (aka APT imaging), and (F) qRPT imaging. Note the significant contrast between tumor and normal tissue in (F), which stems from the Cho phospholipids and may reflect the variation of phospholipid conformation and composition and membrane fluidity. (Phospholipids cause a peak in qRPT spectra but a dip in continuous wave spectra, as in Figure 1). APT, amide proton transfer