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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Ann N Y Acad Sci. 2020 Feb 6;1479(1):94–107. doi: 10.1111/nyas.14311

Figure 5.

Figure 5.

Delayed midazolam (MDZ) failed to prevent the development of spontaneous recurrent seizures (SRS) following GD-induced status epilepticus, independent of sex. Male and female ES1−/− mice were exposed to 82 μg/kg of GD and treated with 3 mg/kg (GD/MDZ3; n = 11) or 9 mg/kg (GD/MDZ9; n = 10) of MDZ at 40 min after seizure onset, and EEG activity was monitored for 14 days after exposure. (A) The onset of the first detected SRS for each surviving animal is graphed to indicate the percentage of mice in each group that developed SRS in the days following GD-induced SE and delayed MDZ treatment. (B) The average (± SD) number of SRS events is graphed for each group.