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. 2021 Jun 9;10:e63698. doi: 10.7554/eLife.63698

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© 2021, Schmidt et al

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Figure 8. — (A) Schematic of MEG-3 function by region. The disordered region (green), ordered C-terminus (white), and HMG-like motif (blue) are indicated. (B) Schematics of one-cell zygotes showing distribution of MEG-3 (green) and PGL-3 (magenta). Wild-type MEG-3 forms robust condensates that recruit RNA and interact with, and enrich, PGL-3 condensates in posterior cytoplasm. MEG-3_Cterm forms condensates that do not recruit RNA but still interact with, and enrich, PGL-3 condensates in posterior. MEG-3_IDR localizes in posterior-rich cytoplasm but does not form condensates, and does not localize PGL-3. MEG-3_HMGL- assembles condensates in posterior cytoplasm that do not recruit RNA and do not interact efficiently with, nor localize, PGL-3 condensates.