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Effects of spermidine on the release of IL-10, IL-1β, and IL-6 in the serum of collagen-induced arthritis (CIA) mice. (A) IL-10 levels; (B) IL-1β levels; (C) IL-6 levels. Data are presented as mean ± standard deviation from five animals and analyzed using single-factor analysis of variance followed by the least significant difference test. **P < 0.01, ***P < 0.001 vs CIA control group.
Abbreviations: CIA, type II collagen (CII)-induced arthritis; SPD, spermidine; DEX, dexamethasone.
