Table 4.

Caregiver-rated most challenging AS symptoms, by age group

Most challenging symptoms	Number of caregivers reporting this AS symptom was challenging, per AS age group
	≤ 5 years	6–12 years	15–17 years
Communication impairment or decreased speech	3	5	4
Seizures	5	2	1
Disruptive behavior	1	3	1
Learning challenges	1	1	1
Walking difficulties	3	2	1
Sleep issues	4	2	1
Ability to use the toilet	1	3	1

Bold, underlined numbers show where three or more caregivers reported this AS symptom as being challenging

AS Angelman syndrome