Table 2.
Cardiopulmonary exercise capacity (per-protocol analysis)
| Baseline | 6 months | p value | Change from baseline | Between-group difference for change from baseline (p value) | |
|---|---|---|---|---|---|
| Primary endpoints | |||||
| Percent-predicted VO2 peak, % | |||||
| Control (n = 33) | 69.6 ± 20.4 | 68.6 ± 20.0 | 0.576 | – 1.03 ± 10.5 | 0.010 |
| APAP (n = 25) | 67.4 ± 17.0 | 73.2 ± 19.2 | 0.003 | + 5.76 ± 8.8 | |
| VO2-AT, mL/kg/min | |||||
| Control (n = 33) | 12.99 ± 2.9 | 12.92 ± 2.9 | 0.863 | – 0.06 ± 2.12 | 0.088 |
| APAP (n = 25) | 12.72 ± 3.4 | 13.67 ± 3.3 | 0.049 | + 0.95 ± 2.30 | |
| Peak VO2, mL/kg/min | |||||
| Control (n = 33) | 15.71 ± 3.9 | 15.68 ± 4.3 | 0.956 | – 0.02 ± 2.48 | 0.064 |
| APAP (n = 25) | 15.01 ± 3.8 | 16.17 ± 4.6 | 0.014 | + 1.16 ± 2.18 | |
| Secondary endpoints | |||||
| VE/VCO2 | |||||
| Control (n = 33) | 29.9 ± 2.8 | 29.5 ± 3.1 | 0.457 | – 0.40 ± 0.52 | 0.012 |
| APAP (n = 25) | 30.8 ± 6.4 | 30.3 ± 6.8 | 0.410 | – 4.3 ± 2.17 | |
| Workload, W | |||||
| Control (n = 33) | 103.0 ± 34.4 | 100.5 ± 33.6 | 0.434 | – 2.52 ± 18.2 | 0.285 |
| APAP (n = 25) | 103.4 ± 35.7 | 107.3 ± 43.8 | 0.478 | + 3.88 ± 26.9 | |
Values are mean ± SD
APAP automatic positive airway pressure, Peak VO2 peak oxygen consumption, VE/VCO2 measure of ventilatory efficiency (minute ventilation relative to carbon dioxide exhalation), VO2-AT maximal oxygen consumption at the anaerobic threshold