Table 3.
Functional capacity, sleepiness and quality of life (per-protocol analysis)
| Baseline | 6 months | p value | Change from baseline | Between-group difference for change from baseline for APAP vs control (p value) | |
|---|---|---|---|---|---|
| 6MWD, m | |||||
| Control (n = 33) | 409.6 ± 104.7 | 419.6 ± 100.4 | 0.566 | 9.3 ± 99.4 | 0.631 |
| APAP (n = 25) | 406.2 ± 66.4 | 390.8 ± 85.0 | 0.170 | – 15.4 ± 72.3 | |
| MLHFQ score | |||||
| Control (n = 33) | 30.88 ± 18.79 | 29.38 ± 19.36 | 0.550 | – 1.3 ± 18.6 | 0.478 |
| APAP (n = 25) | 29.37 ± 20.14 | 24.00 ± 19.66 | 0.037 | – 5.1 ± 19.4 | |
| ESS score | |||||
| Control (n = 33) | 7.24 ± 3.91 | 7.09 ± 5.32 | 0.830 | – 0.1 ± 4.1 | 0.841 |
| APAP (n = 25) | 7.04 ± 4.15 | 6.78 ± 3.40 | 0.743 | – 0.2 ± 3.6 | |
| LVEF, % | |||||
| Control (n = 33) | 36.31 ± 6.91 | 39.23 ± 9.41 | 0.086 | 2.9 ± 7.8 | 0.132 |
| APAP (n = 25) | 39.29 ± 6.51 | 44.35 ± 8.96 | 0.001 | 4.1 ± 7.7 | |
Values are mean ± SD
6MWT six-minute walk test, APAP automatic positive airway pressure, ESS Epworth sleepiness scale, LVEF left ventricular ejection fraction, MLHFQ Minnesota Living with Heart Failure Questionnaire