Table 2:
Cross-sectional associations between sRAGE, elevated liver enzymes and FIB-4 index by quartiles of sRAGE
| Outcome† | sRAGE Quartile | Unadjusted OR (95% CI) | p-value | Adjusted‡ OR (95% CI) | p-value | p-for-trend |
|---|---|---|---|---|---|---|
| Elevated ALT | Q1 | 2.19 (1.01–4.75) | 0.05 | 2.82 (1.18–6.76) | 0.02 | 0.03 |
| Q2 | 1.42 (0.62–3.26) | 0.41 | 1.44 (0.60–3.44) | 0.41 | ||
| Q3 | 1.53 (0.67–3.47) | 0.31 | 1.59 (0.68–3.72) | 0.28 | ||
| Q4 | 1 (Reference) | 1 (Reference) | ||||
| Elevated AST | Q1 | 1.00 (0.43–2.35) | 1.00 | 1.16 (0.45–2.99) | 0.76 | 0.33 |
| Q2 | 1.68 (0.78–3.63) | 0.19 | 1.88 (0.84–4.19) | 0.13 | ||
| Q3 | 0.72 (0.28–1.82) | 0.49 | 0.78 (0.30–2.00) | 0.61 | ||
| Q4 | 1 (Reference) | 1 (Reference) | ||||
| Elevated FIB-4 | Q1 | 0.62 (0.43–0.87) | <0.01 | 0.56 (0.37–0.84) | <0.01 | 0.02 |
| Q2 | 0.83 (0.59–1.17) | 0.30 | 0.86 (0.59–1.24) | 0.42 | ||
| Q3 | 0.74 (0.52–1.04) | 0.08 | 0.75 (0.52–1.08) | 0.12 | ||
| Q4 | 1 (Reference) | 1 (Reference) |
†
Elevated ALT: >27 in Females, >33 in Males; Elevated AST: >31 in Females, >33 in Males; Elevated FIB-4 Index: ≥1.3
‡
Age (ALT and AST analyses only), Race, Gender, Diabetes (yes/no), BMI (kg/m2), Hypertension (yes/no), Total Cholesterol (mg/dL), HDL (mg/dL), Triglycerides (mg/dL), Tobacco Use (current, former, never), Alcohol Use (current, former, never).