Skip to main content
. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: J Heart Lung Transplant. 2021 Mar 29;40(7):557–561. doi: 10.1016/j.healun.2021.03.018

Figure 1: Mechanisms of innate allorecognition and memory.

Figure 1:

This model illustrates the role of SIRPα - CD47 (A) and MHC-I - PIR-A (B) pathways in generating mature dendritic cells and monocyte memory. (A) The balance of activating and inhibitory signals mediated by CD47 and SIRPa on recipient monocytes is skewed towards activation if allogeneic SIRPa is recognized resulting in monocyte maturation to dendritic cells (Mo-DC). (B) Memory monocytes are formed if both PIR-A and CD47 pathways on a subset of monocytes are activated. This leads to clonal expansion and formation of Mo-DC.