Table 5.
Microbiologic Characteristics
| Characteristic | All | Septic Arthritis | Osteomyelitis | Both | ||||
|---|---|---|---|---|---|---|---|---|
| N | Median (IQR) | N | Median (IQR) | N | Median (IQR) | N | Median (IQR) | |
| Duration of bacteremia (days) | 171 | 2.0 (1.0, 4.0) | 16 | 1.5 (1.0, 2.0) | 92 | 2.0 (1.0, 4.0) | 63 | 3.0 (2.0, 4.0) |
| Bacteremia | 419 | 171 (41%) | 118 | 16 (14%) | 203 | 92 (45%) | 98 | 63 (64%) |
| Persistent bacteremia (>72 h) | 419 | 53 (13%) | 118 | 3 (3%) | 203 | 26 (13%) | 98 | 24 (24%) |
| Organism identified by blood or infection site culturea | 448 | 277 (62%) | 132 | 50 (38%) | 213 | 144 (68%) | 103 | 83 (81%) |
| None | 171 (38%) | 82 (62%) | 69 (32%) | 20 (19%) | ||||
| S. aureus | 228 (51%) | 25 (19%) | 127 (60%) | 76 (74%) | ||||
| S. pyogenes | 21 (5%) | 9 (7%) | 7 (3%) | 5 (5%) | ||||
| K. kingae | 5 (1%) | 3 (2%) | 2 (1%) | 0 (0%) | ||||
| S. pneumoniae | 6 (1%) | 4 (3%) | 2 (1%) | 0 (0%) | ||||
| H. influenzae | 2 (0%) | 2 (2%) | 0 (0%) | 0 (0%) | ||||
| Salmonella spp. | 4 (1%) | 0 (0%) | 3 (1%) | 1 (1%) | ||||
| Other organismb | 14 (3%) | 8 (6%) | 4 (2%) | 2 (2%) | ||||
| S. aureus antibiotic resistance | 228 | 25 | 127 | 76 | ||||
| Methicillin | 114 (50%) | 10 (40%) | 61 (48%) | 43 (57%) | ||||
| Clindamycin | 19 (8%) | 3 (12%) | 11 (9%) | 5 (7%) | ||||
| TMP/SMX | 3 (1%) | 1 (4%) | 1 (1%) | 1 (1%) | ||||
| Erythromycin | 126 (55%) | 11 (44%) | 70 (55%) | 45 (59%) | ||||
| MRSA resistance | 114 | 10 | 61 | 43 | ||||
| Clindamycin | 8 (7%) | 2 (20%) | 4 (7%) | 2 (5%) | ||||
| TMP/SMX | 1 (1%) | 0 (0%) | 0 (0%) | 1 (2%) | ||||
| Doxycycline | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | ||||
| Erythromycin | 90 (79%) | 9 (90%) | 49 (80%) | 32 (74%) | ||||
| MSSA resistance | 114 | 15 | 66 | 33 | ||||
| Clindamycin | 11 (10%) | 1 (7%) | 7 (11%) | 3 (9%) | ||||
| TMP/SMX | 2 (2%) | 1 (7%) | 1 (2%) | 0 (0%) | ||||
| Erythromycin | 36 (32%) | 2 (13%) | 21 (32%) | 13 (39%) | ||||
a
Three subjects had polymicrobial infections
b
Other organisms include coagulase negative Staphylococcus, Group C Streptococcus, Group G Streptococcus, viridans group Streptococcus, Leclercia adecarboxylata, Enterobacter asbunae, Enterobacter cloacae, Pseudomonas fluorescens, Bacillus spp.