Table 1:
Baseline characteristics by sTNFR1 tertiles.
| Characteristic | Tertile 1 n=167 |
Tertile 2 n=167 |
Tertile 3 n=166 |
p-value |
|---|---|---|---|---|
| Range, pg/mL | 1,267 to 2,372 | 2,374 to 3,428 | 3,445 to 9,168 | |
| Age, years | 58.1 ± 9.0 | 53.1 ± 10.6 | 51.0 ± 10.9 | <0.001 |
| Female | 67 (40%) | 64 (38%) | 56 (34%) | 0.46 |
| APOL1 risk status | ||||
| Low | 92 (82%) | 83 (71%) | 71 (68%) | 0.05 |
| High | 20 (18%) | 34 (29%) | 33 (32%) | |
| % European ancestry | 17.9 ± 15.2 | 14.6 ± 10.6 | 17.8 ± 11.8 | 0.09 |
| Years of hypertension | 14.4 ± 9.8 | 14.5 ± 9.5 | 13.2 ± 10.5 | 0.40 |
| History of heart disease | 87 (52%) | 90 (54%) | 75 (45%) | 0.24 |
| Systolic BP, mm Hg | 149 ± 25 | 152 ± 25 | 153 ± 23 | 0.39 |
| BMI, kg/m2 | 30.1 ± 5.7 | 31.5 ± 6.4 | 31.0 ± 7.3 | 0.11 |
| Current smoking | 40 (24%) | 44 (26%) | 48 (29%) | 0.59 |
| GFR, ml/min/1.73 m2 | 54.7 ± 7.7 | 47.7 ± 9.1 | 31.7 ± 8.0 | <0.001 |
| Urine PCR, g/g | 0.03 (0.02 to 0.06) |
0.10 (0.03 to 0.32) |
0.37 (0.12 to 0.99) |
<0.001 |
| hsCRP, mg/dL | 0.32 (0.16 to 0.71) |
0.50 (0.24 to 0.97) |
0.46 (0.18 to 0.91) |
0.01 |
| sTNFR2, pg/mL | 8,651 (7,487 to 9,884) |
13,042 (10,962 to 14,735) |
18,972 (15,936 to 22,917) |
<0.001 |
| TNF-α, pg/mL | 2.40 (1.78 to 2.92) |
3.03 (2.27 to 3.93) |
3.74 (2.67 to 4.95) |
<0.001 |
| IFN-γ, pg/mL | 5.23 (3.72 to 7.55) |
5.55 (3.73 to 9.01) |
5.73 (3.95 to 11.68) |
0.12 |
| suPAR, pg/mL | 3,468 (2,821 to 4,334) |
4,463 (3,352 to 5,583) |
5,561 (4,618 to 7,116) |
<0.001 |
| Log2(sTNFR2) | 13.07 ± 0.32 | 13.65 ± 0.32 | 14.24 ± 0.39 | <0.001 |
| Log2(TNF-α) | 1.23 ± 0.61 | 1.56 ± 0.60 | 1.90 ± 0.67 | <0.001 |
| Log2(IFN-γ) | 2.47 ± 0.86 | 2.67 ± 1.15 | 2.86 ± 1.43 | 0.01 |
| Log2(suPAR) | 11.69 ± 0.61 | 12.11 ± 0.57 | 12.47 ± 0.55 | <0.001 |
| BP goal | ||||
| Intensive | 87 (52%) | 79 (47%) | 84 (51%) | 0.67 |
| Standard | 80 (48%) | 88 (53%) | 82 (49%) | |
| Drug group | ||||
| Ramipril | 69 (41%) | 59 (35%) | 67 (40%) | 0.70 |
| Metoprolol | 69 (41%) | 70 (42%) | 67 (40%) | |
| Amlodipine | 29 (17%) | 38 (23%) | 32 (19%) |
Data presented as mean ± standard deviation; number (percent); median (interquartile range).
Abbreviations: BP=blood pressure; BMI=body mass index; GFR=glomerular filtration rate; PCR=protein-to-creatinine ratio; hsCRP=high-sensitivity c-reactive protein; sTNFR1=soluble tumor necrosis factor receptor 1; sTNFR2=soluble tumor necrosis factor receptor 2; TNF-α=tumor necrosis factor alpha; IFN-γ=interferon gamma; suPAR=soluble urokinase-type plasminogen activator receptor.
Data missing for the following variables: APOL1 (n=167); European ancestry (n=167); Years of hypertension (n=3); suPAR (n=14); log2(suPAR) (n=14)