Table 4:

Associations of log₂-transformed biomarkers of immune activation with all-cause mortality in AASK.

Model	n	events	sTNFR1		sTNFR2		TNF-α		IFN-γ
			Hazard Ratio (95% CI)	p-value	Hazard Ratio (95% CI)	p-value	Hazard Ratio (95% CI)	p-value	Hazard Ratio (95% CI)	p-value
Model 0: Unadjusted	500	113	1.65 (1.20, 2.27)	0.002	1.66 (1.23, 2.25)	0.001	1.83 (1.42, 2.34)	<0.001	1.02 (0.87, 1.19)	0.82
Model 1: Adjusted for age and sex	500	113	2.02 (1.46, 2.80)	<0.001	2.10 (1.54, 2.87)	<0.001	2.16 (1.64, 2.83)	<0.001	1.08 (0.92, 1.27)	0.33
Model 2: Model 1 + systolic BP, BMI, and current smoking	500	113	1.90 (1.38, 2.63)	<0.001	1.95 (1.44, 2.65)	<0.001	2.07 (1.57, 2.74)	<0.001	1.10 (0.94, 1.30)	0.23
Model 3: Model 2 + GFR	500	113	2.00 (1.18, 3.39)	0.01	1.98 (1.29, 3.03)	0.002	1.95 (1.44, 2.62)	<0.001	1.09 (0.93, 1.29)	0.29
Model 4: Model 3 + log2(urine PCR)	500	113	2.21 (1.26, 3.85)	0.01	2.07 (1.34, 3.20)	0.001	1.95 (1.45, 2.62)	<0.001	1.09 (0.93, 1.29)	0.29
Model 5: Model 4 + APOL1 risk status and European ancestry	333	55	2.88 (1.31, 6.35)	0.01	2.44 (1.31, 4.54)	0.01	2.14 (1.42, 3.23)	<0.001	1.23 (0.99, 1.52)	0.06

Hazard ratios are per 2-fold higher baseline level of each biomarker.

Abbreviations: BP=blood pressure; GFR=glomerular filtration rate; PCR= protein-to-creatinine ratio; sTNFR1=soluble tumor necrosis factor receptor 1; sTNFR2=soluble tumor necrosis factor receptor 2; TNF-α=tumor necrosis factor alpha; IFN-γ=interferon gamma.