Box 4.

Sample of Attributes to Be Considered in Making a Recommendation Among Alternative Approaches to Estimation of Kidney Function (Estimated GFR)

• Filtration biomarker availability

• Input variable for computation (race, filtration biomarker, age, sex, body composition measure)

• Representation in development and validation of a diverse population with regard to race, ethnicity, sex, age, body composition, severity and cause of kidney disease, and socioeconomic status

• Bias compared with measured kidney function for different race and ethnic groups

• Accuracy compared with measured kidney function for different race and ethnic groups

• Consequences of equation used for clinical decisions with regard to evaluation and management of patients’ kidney function, including health disparities and bias

• Availability of input variables for reporting (race, filtration biomarker, age, sex, body composition measure)

• Feasibility of standardization across the United States

• Patient-centered perspectives on approaches