Table 3.
Mixed-effects linear analysis of plasma NfL with cognitive functions in stratified NfL quartile subgroups.
| Sample size | NfL+ group# | Time | NfL+ group# × time | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Coefficient | p | 95% CI | Coefficient | p | 95% CI | Coefficient | p | 95% CI | ||
| NC group | ||||||||||
| MMSE | 219 | − 0.35 | 0.21 | (− 0.90, 0.19) | − 0.04 | 0.60 | (− 0.19, 0.11) | 0.07 | 0.41 | (− 0.10, 0.24) |
| MMSE orientation | 219 | − 0.01 | 0.86 | (− 0.16, 0.13) | − 0.03 | 0.16 | (− 0.07, 0.01) | − 0.01 | 0.61 | (− 0.06, 0.04) |
| FCSRT | 219 | − 0.91 | 0.48 | (− 3.43, 1.61) | − 0.92 | 0.02 | (− 1.72, − 0.13) | 0.005 | 0.99 | (− 0.89, 0.90) |
| DSST-WAISR | 219 | − 1.18 | 0.49 | (− 4.56, 2.20) | − 0.79 | 0.01 | (− 1.40, − 0.17) | − 0.12 | 0.74 | (− 0.81, 0.58) |
| Category naming | 219 | − 0.07 | 0.96 | (− 2.37, 2.24) | − 0.52 | 0.08 | (− 1.11, 0.06) | 0.01 | 0.97 | (− 0.65, 0.67) |
| CCS | 219 | − 0.05 | 0.63 | (− 0.23, 0.14) | − 0.10 | < 0.001 | (− 0.15, − 0.05) | − 0.03 | 0.33 | (− 0.08, 0.03) |
| MCI group | ||||||||||
| MMSE | 277 | − 0.42 | 0.15 | (− 0.99, 0.15) | − 0.14 | 0.10 | (− 0.31, 0.03) | − 0.05 | 0.57 | (− 0.24, 0.13) |
| MMSE orientation | 277 | − 0.01 | 0.94 | (− 0.20, 0.19) | − 0.09 | 0.01 | (− 0.15, − 0.02) | − 0.07 | 0.07 | (− 0.14, 0.01) |
| FCSRT | 277 | − 2.23 | 0.22 | (− 5.81, 1.34) | − 1.76 | < 0.001 | (− 2.51, − 1.02) | − 0.37 | 0.38 | (− 1.20, 0.46) |
| DSST-WAISR | 277 | − 3.62 | 0.004 | (− 6.10, − 1.14) | − 0.94 | < 0.001 | (− 1.44, − 0.43) | − 0.20 | 0.49 | (− 0.77, 0.37) |
| Category naming | 277 | − 1.70 | 0.13 | (− 3.88, 0.49) | − 0.84 | < 0.001 | (− 1.32, − 0.35) | − 0.17 | 0.54 | (− 0.72, 0.37) |
| CCS | 277 | − 0.21 | 0.04 | (− 0.42, − 0.01) | − 0.16 | < 0.001 | (− 0.21, − 0.11) | − 0.07 | 0.02 | (− 0.12, − 0.01) |
FCSRT free and cued selective reminding test, DSST-WAISR Digit Symbol Substitution Test score from the Wechsler Adult Intelligence Scale—Revised.
#Participants in the non-upper quartile (NfL−) group as the reference.