Figure 6.

Suggested pathway to immune tolerance. An illustration demonstrating the proposed methodology for generation of transplantable, immunologically-acceptable organs for future translation into clinical practice. Donated human placenta (A1) are used to isolate, expand and bank ABO- and HLA-screened, immunologically-acceptable cells (A2). Pig organs (A3) are procured and mounted on a perfusion machine (B) used to rebuild the organ’s vasculature using ABO- and HLA-compatible placental cells. The immunologically-acceptable organ is transplanted into a recipient (C). (Illustration by Noa First Cohen).