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. 2021 Jun 28;12:3987. doi: 10.1038/s41467-021-23899-y

Table 2.

CpGs significantly associated with lipids levels in more than one racial/ethnic group.

CpG RACE BETA SE P MAPINFO GENE GROUP CpG Island Enhancer DHS
HDL
cg17901584* EA 0.032 0.005 1.68 × 10−53 1:55353706 DHCR24 TSS1500 S_Shore
AA 0.036 0.003 3.05 × 10−24
cg24002003 EA 0.010 0.002 2.39 × 10−09 15:101668143 Y Y
AA 0.013 0.002 7.32 × 10−09
cg02650017* EA 0.006 0.001 2.82 × 10−12 17:47301614 PHOSPHO1 Body Island Y
AA 0.005 0.001 9.70 × 10−09
cg06500161* EA −0.021 0.003 6.32 × 10−41 21:43656587 ABCG1 Body S_Shore Y
AA −0.017 0.002 1.45 × 10−11
LDL
cg22930808 EA 0.0001 0.00002 4.38 × 10−08 3:122281881 PARP9 5’UTR N_Shore
AA 0.0002 0.00003 1.18 × 10−09
TG
cg03725309 EA −0.007 0.0011 6.29 × 10−24 1:109757585 SARS Body S_Shore Y
AA −0.008 0.001 2.21 × 10−11
cg16246545 EA −0.011 0.002 1.33 × 10−24 1:120255941 PHGDH Body S_Shore
AA −0.012 0.0019 1.48 × 10−08
cg14476101* EA −0.018 0.003 2.88 × 10−39 1:120255992 PHGDH Body S_Shore
AA −0.020 0.0024 7.53 × 10−15
cg19693031* EA −0.019 0.0021 9.14 × 10−57 1:145441552 TXNIP 3’UTR
AA −0.034 0.0034 1.31 × 10−62
HA −0.028 0.0132 5.76 × 10−9
cg19266329 EA −0.006 0.0008 2.62 × 10−13 1:145456128 Y
AA −0.009 0.0013 1.17 × 10−11
cg19213703 EA −0.005 0.0012 9.42 × 10−08 3:177554561 Y
AA −0.008 0.0019 4.39 × 10−09
cg06690548* EA −0.012 0.0024 2.92 × 10−37 4:139162808 SLC7A11 Body
AA −0.011 0.0011 2.71 × 10−21
cg26403843 EA 0.011 0.002 2.21 × 10−18 5:158634085 RNF145 Body N_Shelf
AA 0.017 0.0022 5.12 × 10−13
cg03717755* EA 0.009 0.001 1.56 × 10−18 6:16136539 MYLIP Body Y
AA 0.011 0.0017 4.87 × 10−15
cg18336453 EA −0.004 0.0008 2.31 × 10−10 6:43082296 PTK7 Body Y
AA −0.007 0.0011 8.87 × 10−10
cg07504977* EA 0.012 0.0016 8.24 × 10−32 10:102131012 N_Shelf Y
AA 0.015 0.002 2.47 × 10−12
cg11376147* EA −0.004 0.0006 3.54 × 10−18 11:57261198 SLC43A1 Body Y Y
AA −0.006 0.001 1.32 × 10−14
cg00574958* EA −0.009 0.0012 1.50 × 10−115 11:68607622 CPT1A 5’UTR N_Shore
AA −0.011 0.0011 2.34 × 10−50
HA −0.013 0.0025 2.65 × 10−14
cg09737197* EA −0.008 0.0013 1.86 × 10−32 11:68607675 CPT1A 5’UTR N_Shore
AA −0.011 0.002 1.38 × 10−15
cg17058475* EA −0.010 0.0013 4.29 × 10−65 11:68607737 CPT1A 5’UTR N_Shore
AA −0.011 0.0025 8.52 × 10−28
cg10919522 EA −0.005 0.001 5.59 × 10−08 14:74227441 C14orf43 5’UTR S_Shore Y
AA −0.010 0.0014 1.02 × 10−10
cg15863539* EA 0.003 0.0009 8.83 × 10−17 17:17716950 SREBF1 Body S_Shore
AA 0.004 0.0006 1.93 × 10−09
cg20544516* EA 0.006 0.0006 3.71 × 10−25 17:17717183 MIR33B;SREBF1 Body;Body S_Shore
AA 0.007 0.0008 3.18 × 10−14
cg11024682* EA 0.010 0.0013 1.08 × 10−50 17:17730094 SREBF1 Body S_Shelf
AA 0.016 0.0013 5.77 × 10−28
HA 0.019 0.0033 1.59 × 10−8
cg08857797* EA 0.006 0.001 1.93 × 10−12 17:40927699 VPS25 Body
AA 0.008 0.0017 1.73 × 10−10
cg22304262 EA −0.006 0.0012 6.04 × 10−12 19:47287778 SLC1A5 Body;5’UTR N_Shelf
AA −0.008 0.0012 3.31 × 10−08
cg08309687 EA −0.009 0.0017 4.49 × 10−14 21:35320596 Y Y
AA −0.014 0.0024 3.00 × 10−11
cg0188189* EA 0.005 0.0008 6.07 × 10−21 21:43652704 ABCG1 Body N_Shelf
AA 0.007 0.0011 1.21 × 10−17
cg02370100* EA 0.005 0.0008 1.45 × 10−13 21:43655256 ABCG1 Body Island
AA 0.006 0.0014 1.49 × 10−08
cg07397296 EA 0.007 0.0012 4.68 × 10−16 21:43655316 ABCG1 Body Island Y
AA 0.007 0.0012 3.98 × 10−08
cg06500161* EA 0.016 0.0015 4.73 × 10−111 21:43656587 ABCG1 Body S_Shore Y
AA 0.017 0.0023 2.72 × 10−39
HA 0.021 0.0033 7.68 × 10−10

*Identified in previous epigenome-wide association of lipids; SD Standard error, CHR Chromosome, DHS DNase I hypersensitive site, HDL high-density lipoprotein, LDL low-density lipoprotein, TG triglycerides, EA European ancestry, AA African ancestry, HA Hispanic ancestry, NEA = 11,114, NAA = 4,452, NHA = 699; The statistic is a likelihood ratio test (LRT) which asymptotically follows an equal mixture of 1 degree of freedom (df) χ2 distribution and 2 df χ2 distribution; CI can be calculated as (BETA-1.96*SE, BETA + 1.96*SE). A p-value was considered significant in a specific racial/ethnic group if it was <1.09 × 10−7 (Bonferroni correction for the number of CpG probes tested).