Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 28;12:4001. doi: 10.1038/s41467-021-24220-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Following principal component analysis, core AD principal component (PC) score corresponding to t-Tau/Aβ42 of 0.39 (predicted ADNC threshold) and sTNFR1 PC score corresponding to no net decline at this core AD score were used to stratify ADNI mild cognitive impairment (MCI) participants (A). Circle colors represent follow-up time, with converters shown as filled circles and non-converters shown as open circles. Participants with high core AD and low sTNFR1 scores had the shortest median time to conversion, followed by those with high scores in both and those with low core AD score (B *p = 0.014 with dementia diagnosis as outcome; ^†p = 0.007 with clinical dementia rating-sum of boxes score [CDR-SB] ≥ 4 as outcome). Source data are provided as a Source Data file.