Fig. 2. Relationship between two protein family scores (core AD and sTREM2) and cognitive decline in AD dementia.

AD dementia participants with high core AD and sTREM2 scores had slower conversion to a pre-set CDR-SB threshold (1.5 S.D. above the mean) than participants with low sTREM2 scores (a *p = 0.001). Concentrations of two proteins which did (sTREM2 and progranulin) and one did not (sTNFR1) load onto sTREM2 score showed greatest group-level differences in sTREM2 (b median and interquartile ranges shown). Substituting corresponding p-Tau₁₈₁ and sTREM2 concentrations (shown in brackets to distinguish from a) for corresponding scores modestly reproduced the distinction (c ^†p = 0.028). Source data are provided as a Source Data file.