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. 2021 Jun 28;12:4004. doi: 10.1038/s41467-021-24241-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Raw data labeling from two separate cases of retrograde injections into the SC. Top row: CTB (pink) injection into SC.m, CTB (red) injection into SC.cl, and CTB (green) injection into SC.l. Cells are topographically retrogradely labeled in VMH domains and cortex. Bottom row: CTB (red) injection in SC.cm, and FG injection in SC.l. b Raw connectivity data in SC (all at ARA 90) from three separate anterograde injections in the ZI. The ZI.l (lateral part) targets SC.m/cm; the ZI.c (center part) targets SC.cl, and the ZI.m (medial part) targets SC.l. c Raw connectivity data in SC (all at ARA 90) from three separate FG injections in different thalamic nuclei, RE (top), MD (middle) or PF.m (bottom), and the respective retrogradely-labeled thalamic projections neurons, respectively, in SC.m/cm, SC.cl, or SC.l. Cells were distributed heterogeneously across superficial, intermediate and deep layers, but clustered topographically and preferentially in distinct zones. Scale bar 200 µm in SC panels. d Labeling produced from anterograde injections into distinct SNr domains project to SC. e Topographic organization of mouse SC connectivity. Directional cross at bottom left. The four zones of the SC are connected either uni- or bi-directionally with cortex, PF, ZI, VMH, and SNr. Plus signs and minus signs indicate excitatory or inhibitory projections, respectively. f Dendrites from LD-, RE-, and PF/PT-projecting SC neurons were reconstructed to visualize differences and dendritic arborizations across SC layers and zones. Examples of reconstructed neurons were overlapped onto reconstructions of cortico-tectal projections on the SC atlas. This facilitates analysis of spatial correlation between cortical projection fields and dendritic fields of SC-projection neurons. Color-code associations: red (SC.m), orange (SC.cm), green (SC.cl), purple (SC.l). See Supplementary Table 1 for complete list of abbreviations.