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. 2021 Jun 28;12:4004. doi: 10.1038/s41467-021-24241-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Integration of SC.cl and SC.l zones in visuomotor, somatic sensorimotor, escape and approach subnetworks. SC.cl/l neurons receive inputs from MO/SS (orofacial, barrel field, upper limb) cortices, motor-related domains from thalamic nuclei (PF.mouth, PF.upper limb, VM, PCN), sexual approach behavior (VMH.vl) and orofacial/upper-limb brainstem and cerebellar inputs. This input provides evidence for SC.cl/l zones as distinct somatic sensorimotor subnetworks that mediate a subset of behaviors distinct from the more visually integrated range of behaviors mediated through SC.m/cm. Our network analysis reveals the segregation of ventromedial prefrontal cortex (vmPFC) outputs from ORB and ILA regions to functionally specific SC.cl/l zones. These prefrontal regions also project densely to VMH, ZI and PAG, with BLA sharing bilateral connections with ILA⁸¹). b SC.m and SC.cm integration of visual information with spatial-related and head-direction hippocampal networks²⁵, attention/orienting regions and freezing/defense regions. See Supplementary Table 1 for complete abbreviation list.