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. 2021 Jun 28;11:13380. doi: 10.1038/s41598-021-92790-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increase in lipid and fatty acid absorption in the intestine of nonalcoholic steatohepatitis (NASH) rats. (A) Time-dependent increase in triglyceride (TG) level in the plasma of each model rat upon infusion of lipid emulsion and Triton (N = 6 per group; + P < 0.05, NASH vs. control; *P < 0.05, NAFL vs. control; ☨P < 0.01, NASH vs. control). Changes in (B) total chylomicron (CM) particle number, (C) chylomicron TG (CM-TG) concentration, (D) palmitic acid concentration before and 180 min after the meal using HPLC and gas chromatography, respectively (N = 6 per group; *P < 0.05; **P < 0.01). (E) Lipid absorption coefficient (LAC) in each group. LAC was measured when all the three groups of animals were fed the same diet (MFD) (N = 6 per group; *P < 0.05, **P < 0.01). Data in bar plots are shown as the mean ± standard deviation. Statistical analysis between the three groups was performed using Kruskal–Wallis ANOVA. Tukey's multiple comparison test was performed only when a significant difference was found.