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. 2021 Jun 28;12(7):656. doi: 10.1038/s41419-021-03938-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Pancreatic cancer cell line SW1990 or PANC-1 was transfected with negative control (shNC) or shRNA targeting circ-0005105 (sh-circ-0005105 #1/2/3). The relative expression levels of circ-0005105 (A) or SEC24A mRNA (B) were analyzed by qRT-PCR. Cell proliferation capability of SW1990 or PANC-1 cells transfected with sh-NC or sh-circ-0005105 #2/3 was determined by CCK-8 assay (C), colony formation assay (F), and EdU assay (E); Scale bar = 50 μm. F Cell apoptosis was determined by TUNEL assay; Scale bar = 50 μm. G Transwell experiment was performed to analyze the cell invasion capability of SW1990 or PANC-1 cells transfected with sh-NC or sh-circ-0005105 #2/3; Scale bar = 50 μm. H Expression levels of MMP-2, MMP-7, and MMP-9 in SW1990 or PANC-1 transfected with sh-NC or sh-circ-0005105 #2/3 were analyzed by western blot. The results are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.