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. 2021 Jun 28;12(7):656. doi: 10.1038/s41419-021-03938-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Pancreatic cancer cell PANC-1 stably transfected with negative control (sh-NC) or sh-circ-0005105 #2/3 were intravenous injected into nude mice. A Tumors from sh-NC or sh-circ-0005105 #2/3 group were isolated from nude mice and tumor weight was examined. B Representative bioluminescent photos were recorded at 1, 3, 5 weeks post injection. Relative luciferase activity was analyzed in sh-NC or sh-circ-0005105 #2/3 group. C Tumor volume was measured and determined at indicated time points. D Representative H&E staining and immunohistochemical staining image of Ki-67 were acquired on tumor sections from sh-NC or sh-circ-0005105 #2/3 group. Relative Ki-67 staining intensity in sh-NC or sh-circ-0005105 #2/3 group was analyzed. Scale bar = 200 μm. E Representative results of gross and H&E staining of metastatic lung nodules in different groups. Scale bars, 500 μm. The results are presented as the mean ± SD for each group (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001.