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. 2021 Jun 28;12(7):656. doi: 10.1038/s41419-021-03938-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A, B KEGG pathway enrichment analysis of COL11A1 related pathways in TCGA PAAD dataset. C Gene set variation analysis (GSVA) and (D)The Gene Set Enrichment Analysis (GSEA) of the relationship between the expression level of COL11A1 and EMT-related gene signatures in the TCGA PAAD dataset. E, F Expression change of EMT-related proteins (N-cadherin, E-cadherin, β-catenin, Snail, Slug, and Twist) in pancreatic cells and xenograft mouse models bearing tumors under condition of COL11A1 silencing. G Expression change of EMT-related proteins (N-cadherin, E-cadherin, β-catenin, Snail, Slug, and Twist) in pancreatic cells after indicated transfection. The results are presented as the mean ± SD for each group. *P < 0.05, **P < 0.01, ***P < 0.001.