Table 3:
Unadjusted and adjusted cox hazard model for hazard of pre-transplant death, by early/late evaluation (use 30 days as cutoff)
| Univariable | Multivariable | ||||
|---|---|---|---|---|---|
|
| |||||
| Parameter | Value | HR (95%CI) | P | aHR (95%CI) | P |
|
| |||||
| Time from referral to evaluation | Late Evaluation | REF | REF | ||
| Early Evaluation | 0.74 (0.58,0.94) | 0.0125 | 0.70 (0.54,0.91) | 0.0070 | |
|
| |||||
| Age | Age at Referral | 1.02 (1.00,1.04) | 0.0403 | 1.03 (1.01,1.05) | 0.0025 |
|
| |||||
| Center | Station 1 | REF | REF | ||
| Station 2 | 0.59 (0.36,0.98) | 0.0420 | 0.56 (0.33,0.97) | 0.0371 | |
| Station 3 | 0.68 (0.46,1.01) | 0.0565 | 0.64 (0.42,0.99) | 0.0456 | |
| Station 4 | 1.22 (0.87,1.70) | 0.2493 | 1.03 (0.72,1.47) | 0.8849 | |
| Station 5 | 0.70 (0.46,1.08) | 0.1103 | 0.64 (0.40,1.02) | 0.0595 | |
| Station 6 | 0.79 (0.53,1.20) | 0.2757 | 0.84 (0.53,1.32) | 0.4441 | |
|
| |||||
| Etiology | NAFLD | REF | REF | ||
| Autoimmune hepatitis | 0.67 (0.16,2.76) | 0.5751 | 0.63 (0.12,3.27) | 0.5842 | |
| Cryptogenic Cirrhosis | 1.33 (0.32,5.50) | 0.6985 | 1.75 (0.32,9.66) | 0.5193 | |
| Alcohol | 0.70 (0.47,1.05) | 0.0859 | 0.58 (0.37,0.90) | 0.0146 | |
| HBV | 0.59 (0.23,1.51) | 0.2714 | 0.63 (0.24,1.65) | 0.3461 | |
| HCV | 0.69 (0.45,1.06) | 0.0865 | 0.63 (0.38,1.02) | 0.0614 | |
| HCV + Alcohol | 0.81 (0.56,1.17) | 0.2534 | 0.80 (0.51,1.26) | 0.3342 | |
| HFE | 0.50 (0.16,1.63) | 0.2524 | 0.67 (0.20,2.31) | 0.5289 | |
| PBC | 0.83 (0.40,1.72) | 0.6123 | 0.84 (0.41,1.70) | 0.6200 | |
| PSC | 2.00 (0.84,4.75) | 0.1154 | 1.55 (0.74,3.23) | 0.2414 | |
|
| |||||
| Gender | Male | REF | REF | ||
| Female | 1.52 (0.83,2.78) | 0.1731 | 1.78 (0.95,3.31) | 0.0712 | |
|
| |||||
| Race/Ethnicity | White | REF | REF | ||
| Black | 0.83 (0.59,1.17) | 0.2808 | 0.75 (0.52,1.08) | 0.1173 | |
| Other | 2.08 (1.39,3.11) | 0.0004 | 2.46 (1.60,3.77) | <.0001 | |
| Hispanic / Latino | 0.97 (0.65,1.44) | 0.8674 | 1.07 (0.67,1.70) | 0.7905 | |
| Unknown | 0.66 (0.36,1.21) | 0.1753 | 0.64 (0.33,1.25) | 0.1903 | |
|
| |||||
| BMI at referral | Normal Weight | REF | REF | ||
| Underweight | 1.27 (0.61,2.67) | 0.5257 | 1.49 (0.72,3.11) | 0.2862 | |
| Overweight | 0.86 (0.62,1.19) | 0.3573 | 1.01 (0.72,1.42) | 0.9522 | |
| Obese | 1.00 (0.73,1.37) | 0.9870 | 1.18 (0.84,1.66) | 0.3463 | |
|
| |||||
| Diabetes at referral | No | REF | REF | ||
| Yes | 0.71 (0.56,0.89) | 0.0029 | 0.67 (0.53,0.86) | 0.0013 | |
|
| |||||
| Tobacco Use at Diagnosis of Cirrhosis | Never smoker | REF | REF | ||
| Current smoker | 1.20 (0.91,1.57) | 0.2059 | 1.11 (0.80,1.53) | 0.5432 | |
| Former smoker | 1.29 (0.95,1.75) | 0.1007 | 1.22 (0.89,1.66) | 0.2193 | |
| Unknown | 1.49 (0.54,4.05) | 0.4398 | 1.83 (0.72,4.67) | 0.2035 | |
|
| |||||
| AUDIT-C Score at referral | Low | REF | REF | ||
| High | 1.10 (0.78,1.54) | 0.5928 | 1.17 (0.8,1.71) | 0.4153 | |
|
| |||||
| HCV viremia at referral | No | REF | REF | ||
| Yes | 1.03 (0.8,1.33) | 0.8107 | 1.04 (0.76,1.41) | 0.8172 | |
|
| |||||
| Cirrhosis comorbidity index at referral | 0 | REF | REF | ||
| 1+0 | 1.14 (0.86,1.50) | 0.3564 | 1.26 (0.92,1.73) | 0.1486 | |
| 1+1 | 1.28 (0.79,2.08) | 0.3116 | 1.39 (0.80,2.42) | 0.2363 | |
| 3+0 | 1.49 (0.85,2.61) | 0.1638 | 1.18 (0.62,2.23) | 0.6129 | |
| 3+1 | 1.55 (0.84,2.85) | 0.1580 | 1.53 (0.85,2.75) | 0.1552 | |
|
| |||||
| CAD at referral | No | REF | REF | ||
| Yes | 1.11 (0.86,1.45) | 0.4221 | 1.14 (0.87,1.50) | 0.3340 | |
|
| |||||
| Liver cancer at referral | No | REF | REF | ||
| Yes | 0.82 (0.65,1.03) | 0.0842 | 0.68 (0.22,0.94) | <.0001 | |
|
| |||||
| Disease within Milan criteria at referral | No | REF | REF | ||
| Yes | 0.57 (0.34,0.94) | 0.0279 | 0.13 (0.05,0.31) | <.0001 | |
|
| |||||
| Down-staging of HCC | No | REF | REF | ||
| Yes | 0.30 (0.12,0.78) | 0.0130 | 0.27 (0.10,0.77) | 0.0142 | |
|
| |||||
| Tumor progression while waiting | No | REF | REF | ||
| Yes | 2.59 (1.83,3.67) | <.0001 | 2.69 (1.88,3.84) | <.0001 | |
|
| |||||
| BCLC staging at listing | 0 | REF | REF | ||
| A | 2.49 (1.26,4.92) | 0.0085 | 2.70 (1.37,5.33) | 0.0041 | |
| B | 1.27 (0.51,3.21) | 0.6083 | 0.68 (0.23,1.99) | 0.4814 | |
|
| |||||
| Distance (in miles) | Distance from referring VA to transplant center in miles | 0.99 (0.99,1.01) | 0.3970 | 0.99 (0.99,1.01) | 0.8634 |
|
| |||||
| MELD at referral | MELD Score at Referral | 1.03 (1.01,1.04) | <.0001 | 1.04 (1.02,1.06) | <.0001 |