Table 4:
Univariate and multivariate logistic regression model for predictors of transplant list drop-out, by early (≤30 days) versus late (>30 days) time from referral to evaluation
| Univariable | Multivariable | ||||
|---|---|---|---|---|---|
|
| |||||
| Parameter | Value | OR (95%CI) | P | aOR (95%CI) | P |
|
| |||||
| Time from referral to evaluation | Late Evaluation | REF | REF | ||
| Early Evaluation | 0.82 (0.59,1.13) | 0.2205 | 0.95 (0.65,1.39) | 0.8030 | |
|
| |||||
| Age | Age at Referral | 1.02 (0.99,1.04) | 0.1443 | 1.02 (0.99,1.04) | 0.2379 |
|
| |||||
| Center | Station 1 | REF | REF | ||
| Station 2 | 0.33 (0.18,0.62) | 0.0109 | 0.29 (0.15,0.57) | <.0001 | |
| Station 3 | 0.28 (0.17,0.47) | <.0001 | 0.28 (0.16,0.48) | <.0001 | |
| Station 4 | 0.96 (0.64,1.44) | 0.1814 | 0.90 (0.57,1.41) | 0.1268 | |
| Station 5 | 0.38 (0.22,0.66) | 0.0136 | 0.34 (0.18,0.63) | 0.0214 | |
| Station 6 | 0.26 (0.15,0.47) | <.0001 | 0.27 (0.14,0.51) | 0.0123 | |
|
| |||||
| Etiology | NAFLD | REF | REF | ||
| Autoimmune hepatitis | 1.84 (0.34,9.91) | 0.6630 | 2.92 (0.45,19.06) | 0.3746 | |
| Cryptogenic Cirrhosis | 1.11 (0.12,10.06) | 0.8553 | 1.46 (0.14,15.07) | 0.9610 | |
| Alcohol | 1.59 (0.88,2.86) | 0.4269 | 1.39 (0.74,2.62) | 0.9888 | |
| HBV | 0.79 (0.21,2.94) | 0.3743 | 0.83 (0.20,3.40) | 0.4124 | |
| HCV | 1.47 (0.79,2.73) | 0.6755 | 1.45 (0.70,3.00) | 0.8653 | |
| HCV + Alcohol | 1.36 (0.77,2.41) | 0.9032 | 1.17 (0.59,2.32) | 0.5269 | |
| HFE | 1.19 (0.31,4.57) | 0.8505 | 1.50 (0.35,6.36) | 0.9011 | |
| PBC | 2.01 (0.77,5.25) | 0.3163 | 1.93 (0.69,5.40) | 0.4604 | |
| PSC | 1.38 (0.27,7.08) | 0.9552 | 1.07 (0.19,6.09) | 0.7399 | |
|
| |||||
| Gender | Male | REF | REF | ||
| Female | 0.60 (0.21,1.74) | 0.3465 | 0.61 (0.20,1.87) | 0.3850 | |
|
| |||||
| Race/Ethnicity | White | REF | REF | ||
| Black | 0.84 (0.49,1.42) | 0.7917 | 0.92 (0.57,1.49) | 0.4866 | |
| Other | 0.88 (0.58,1.33) | 0.5892 | 1.09 (0.51,2.33) | 0.3211 | |
| Hispanic / Latino | 0.86 (0.43,1.69) | 0.7712 | 0.79 (0.43,1.42) | 0.9785 | |
| Unknown | 0.48 (0.22,1.08) | 0.1451 | 0.39 (0.16,0.95) | 0.0557 | |
|
| |||||
| BMI at referral | Normal Weight | REF | REF | ||
| Underweight | 0.38 (0.09,1.67) | 0.1837 | 0.33 (0.07,1.63) | 0.1101 | |
| Overweight | 1.00 (0.66,1.52) | 0.2703 | 1.25 (0.78,2.01) | 0.0936 | |
| Obese | 1.04 (0.68,1.57) | 0.1957 | 1.29 (0.80,2.08) | 0.0725 | |
|
| |||||
| Diabetes at referral | No | REF | REF | ||
| Yes | 0.61 (0.46,0.82) | 0.0012 | 0.60 (0.43,0.84) | 0.0031 | |
|
| |||||
| Tobacco Use at Diagnosis of Cirrhosis | Never smoker | REF | REF | ||
| Current smoker | 1.08 (0.76,1.53) | 0.9629 | 1.10 (0.73,1.67) | 0.8619 | |
| Former smoker | 1.13 (0.77,1.67) | 0.9623 | 1.03 (0.66,1.59) | 0.8661 | |
|
| |||||
| AUDIT-C Score at referral | Low | REF | REF | ||
| High | 0.93 (0.59,1.47) | 0.7682 | 0.86 (0.51,1.43) | 0.5592 | |
|
| |||||
| HCV viremia at referral | No | REF | REF | ||
| Yes | 1.04 (0.75,1.46) | 0.8089 | 0.87 (0.56,1.36) | 0.5482 | |
|
| |||||
| Cirrhosis comorbidity index at referral | 0 | REF | REF | ||
| 1+0 | 0.98 (0.68,1.41) | 0.9683 | 0.89 (0.59,1.35) | 0.9700 | |
| 1+1 | 1.48 (0.80,2.75) | 0.9591 | 1.37 (0.68,2.77) | 0.9604 | |
| 3+0 | 0.89 (0.38,2.05) | 0.9705 | 0.78 (0.31,1.97) | 0.9731 | |
| 3+1 | 1.54 (0.67,3.55) | 0.9582 | 1.54 (0.62,3.80) | 0.9578 | |
|
| |||||
| CAD at referral | No | REF | REF | ||
| Yes | 0.93 (0.65,1.33) | 0.6753 | 0.95 (0.64,1.41) | 0.8063 | |
|
| |||||
| Liver cancer at referral | No | REF | REF | ||
| Yes | 0.93 (0.69,1.24) | 0.6133 | 0.57 (0.18,1.89) | 0.3598 | |
|
| |||||
| Disease within Milan criteria at referral | No | REF | REF | ||
| Yes | 1.52 (0.70,3.33) | 0.3923 | 1.61 (0.39,6.60) | 0.8992 | |
|
| |||||
| Down-staging of HCC | No | REF | REF | ||
| Yes | 3.5 (0.39,31.12) | 0.3864 | 3.93 (0.33,46.72) | 0.2759 | |
|
| |||||
| Tumor progression while waiting | No | REF | REF | ||
| Yes | 5.04 (3.20,7.95) | <.0001 | 4.89 (2.96,8.08) | <.0001 | |
|
| |||||
| BCLC staging at listing | 0 | REF | REF | ||
| A | 0.87 (0.47,1.59) | 0.9663 | 0.98 (0.50,1.92) | 0.9684 | |
| B | 0.50 (0.20,1.27) | 0.9715 | 0.60 (0.19,1.82) | 0.9749 | |
|
| |||||
| Distance (in miles) | Distance from referring VA to transplant center in miles | 0.99 (0.99,1.01) | 0.0931 | 0.99 (0.99,1.01) | 0.1123 |
|
| |||||
| MELD at referral | MELD Score at Referral | 1.00 (0.98,1.02) | 0.7692 | 1.01 (0.98,1.03) | 0.6676 |