Table 5:
Univariate and multivariate logistic regression model for predictors of early (≤30 days) time from referral to evaluation
| Univariable | Multivariable | ||||
|---|---|---|---|---|---|
|
| |||||
| Parameter | Value | OR (95%CI) | P | aOR (95%CI) | P |
|
| |||||
| Age | Age at Referral | 1.00 (0.98,1.02) | 0.7401 | 1.00 (0.98,1.03) | 0.7769 |
|
| |||||
| Center | Station 1 | REF | REF | ||
| Station 2 | 1.10 (0.62,1.96) | 0.6093 | 1.17 (0.63,2.16) | 0.6233 | |
| Station 3 | 1.43 (0.87,2.35) | 0.4393 | 1.52 (0.90,2.58) | 0.4446 | |
| Station 4 | 0.62 (0.40,0.95) | <.0001 | 0.62 (0.39,0.99) | <.0001 | |
| Station 5 | 0.23 (0.14,0.37) | <.0001 | 0.24 (0.14,0.41) | <.0001 | |
| Station 6 | 16.07 (4.86,53.17) | <.0001 | 19.25 (5.72,64.85) | <.0001 | |
|
| |||||
| Etiology | NAFLD | REF | REF | ||
| Autoimmune hepatitis | 0.54 (0.12,2.39) | 0.3124 | 0.45 (0.09,2.25) | 0.3110 | |
| Cryptogenic Cirrhosis | 1.61 (0.18,14.37) | 0.6783 | 1.46 (0.12,17.44) | 0.6988 | |
| Alcohol | 1.27 (0.75,2.14) | 0.4332 | 1.26 (0.70,2.27) | 0.2590 | |
| HBV | 1.61 (0.51,5.12) | 0.4292 | 1.05 (0.29,3.83) | 0.8582 | |
| HCV | 0.75 (0.44,1.27) | 0.1277 | 0.73 (0.38,1.41) | 0.3557 | |
| HCV + Alcohol | 0.82 (0.51,1.33) | 0.2103 | 0.84 (0.46,1.56) | 0.6593 | |
| HFE | 1.50 (0.40,5.62) | 0.5645 | 1.36 (0.31,5.86) | 0.5842 | |
| PBC | 0.88 (0.35,2.21) | 0.6543 | 1.09 (0.40,2.97) | 0.7522 | |
| PSC | 1.29 (0.26,6.43) | 0.7945 | 0.71 (0.12,4.20) | 0.7210 | |
|
| |||||
| Gender | Male | REF | REF | ||
| Female | 0.68 (0.31,1.47) | 0.3265 | 1.04 (0.41,2.64) | 0.9404 | |
|
| |||||
| Race/Ethnicity | White | REF | REF | ||
| Black | 0.79 (0.50,1.25) | 0.0896 | 0.67 (0.43,1.05) | 0.0728 | |
| Other | 0.94 (0.65,1.37) | 0.3304 | 2.29 (1.01,5.21) | 0.0197 | |
| Hispanic / Latino | 1.66 (0.82,3.35) | 0.1698 | 0.93 (0.54,1.60) | 0.1876 | |
| Unknown | 1.39 (0.72,2.66) | 0.4265 | 2.24 (1.07,4.67) | 0.0112 | |
|
| |||||
| BMI at referral | Normal Weight | REF | REF | ||
| Underweight | 1.29 (0.46,3.66) | 0.6652 | 0.95 (0.30,3.02) | 0.9339 | |
| Overweight | 1.16 (0.79,1.71) | 0.7145 | 1.17 (0.75,1.81) | 0.3418 | |
| Obese | 0.96 (0.66,1.40) | 0.3949 | 0.85 (0.55,1.33) | 0.4068 | |
|
| |||||
| Diabetes at referral | No | REF | REF | ||
| Yes | 1.07 (0.81,1.41) | 0.6576 | 1.19 (0.86,1.64) | 0.2943 | |
|
| |||||
| Tobacco Use at Diagnosis of Cirrhosis | Never smoker | REF | REF | ||
| Current smoker | 0.78 (0.56,1.08) | 0.3167 | 0.75 (0.50,1.12) | 0.1614 | |
| Former smoker | 0.71 (0.49,1.02) | 0.1621 | 0.77 (0.51,1.17) | 0.1978 | |
| Unknown | 1.55 (0.34,7.16) | 0.4065 | 2.14 (0.40,11.42) | 0.2662 | |
|
| |||||
| AUDIT-C Score at referral | Low | REF | REF | ||
| High | 1.59 (1.01,2.51) | 0.0464 | 1.50 (0.90,2.52) | 0.1235 | |
|
| |||||
| HCV viremia at referral | No | REF | REF | ||
| Yes | 0.88 (0.65,1.19) | 0.3956 | 1.29 (0.87,1.92) | 0.2093 | |
|
| |||||
| Cirrhosis comorbidity index at referral | 0 | REF | REF | ||
| 1+0 | 0.98 (0.70,1.36) | 0.9607 | 1.06 (0.72,1.57) | 0.9615 | |
| 1+1 | 0.66 (0.37,1.17) | 0.9510 | 0.80 (0.41,1.55) | 0.9546 | |
| 3+0 | 0.98 (0.47,2.05) | 0.9608 | 1.10 (0.48,2.54) | 0.9624 | |
| 3+1 | 1.62 (0.61,4.31) | 0.9731 | 1.66 (0.59,4.69) | 0.9724 | |
|
| |||||
| CAD at referral | No | REF | REF | ||
| Yes | 1.24 (0.88,1.73) | 0.2189 | 1.09 (0.75,1.59) | 0.6470 | |
|
| |||||
| Liver cancer at referral | No | REF | REF | ||
| Yes | 0.88 (0.67,1.15) | 0.3537 | 1.15 (0.40,3.29) | 0.8015 | |
|
| |||||
| Disease within Milan criteria at referral | No | REF | REF | ||
| Yes | 1.21 (0.66,2.21) | 0.8385 | 4.31 (1.30,14.35) | 0.6822 | |
|
| |||||
| Down-staging of HCC | No | REF | REF | ||
| Yes | 0.44 (0.08,2.34) | 0.4979 | 0.64 (0.09,4.82) | 0.5828 | |
|
| |||||
| Tumor progression while waiting | No | REF | REF | ||
| Yes | 1.27 (0.80,2.01) | 0.5055 | 1.50 (0.88,2.55) | 0.9973 | |
|
| |||||
| BCLC staging at listing | 0 | REF | REF | ||
| A | 0.45 (0.23,0.88) | <.0001 | 0.46 (0.23,0.93) | <.0001 | |
| B | 0.64 (0.27,1.54) | 0.9760 | 0.71 (0.26,1.99) | 0.9869 | |
|
| |||||
| Distance (in miles) | Distance from referring VA to transplant center in miles | 0.99 (0.99,0.99) | <.0001 | 0.99 (0.99,0.99) | <.0001 |
|
| |||||
| MELD at referral | MELD Score at Referral | 1.02 (1.01,1.04) | 0.0205 | 1.03 (1.00,1.05) | 0.0188 |