Table 3 –

Association of ROP Severity & Treatment with Light Fundus Pigmentation

Fundus pigmentation	ROP Status N (%)#		Plus Disease N (%)		Zone Severity N (%)		Stage Severity N (%)			Treatment Type N (%)
	Yes	No	Yes	No	Zone 1	Zone 2 &3	Stage 1	Stage 2	Stage 3	IVB	Laser
Light	162	334	38	458	37	125	70	87	5	38	7
496	(33%)	(67%)	(7.7%)	(92%)	(7.5%)	(25%)	(14%)	(18%)	(1.0%)	(7.7%)	(1.4%)
Medium/Dark	198	565	23	740	25	169	99	86	13	23	8
763	(26%)	(74%)	(3.0%)	(97%)	(3.3%)	(22%)	(13%)	(11%)	(1.7%)	(3.0%)	(1.0%)
Total	360	899	61	1198	62	294	169	173	18	68	15
1259	(29%)	(71%)	(4.8%)	(95%)	(4.9%)	(23%)	(13%)	(14%)	(1.4%)	(5.4%)	(1.2%)
Odds of ROP (OR [95% CI] p-value)	1.38 [1.08–1.77] p = 0.01b		4.01 [2.00–8.04] p > 0.01a	2.50 [1.48–4.23] p > 0.01b		1.22 [0.94–1.60] p = 0.14ǂ, b	1.57 [1.08–2.3] p = 0.02a	1.92 [1.27–2.9] p > 0.01a	*	2.67 [1.57–4.54] p > 0.01b	*

^ǂZone 2 & 3 had reduced odds of light fundus pigmentation as compared to Zone 1 (OR 0.49, p = 0.01);

^*Associations for stage 3 severity and treatment with laser were not statistically significant; all analyses performed with logistic regression;

^aforward stepwise multivariable logistic regression

^bunivariable logistic regression

^#percentages expressed respective to fundus pigmentation groups; Abbreviations: ROP = retinopathy of prematurity, OR = odds ratio, CI = confidence interval, IVB = intravitreal bevacizumab