TABLE 1.

Available laboratory assay data from each trial. Bolded data are data used in this integration.

MAL068			MAL071
Data type	Source lab	Reference	Data type	Source lab	Reference
Gene expression
Microarray	Emory	Kazmin et al. (2017)
RNA-seq	CIDR	Du et al. (2020)	RNA-seq	CIDR, Emory	Du et al. (2020)
Cellular
ICS	GSK	Ockenhouse et al. (2015); Kazmin et al. (2017)	ICS e	GSK, U Miami	Regules et al. (2016); Pallikkuth et al. (2020)
T-cell ELISpot	Crucell/Janssen	Ockenhouse et al. (2015)	Peripheral follicular helper cell (pTfh) frequency and function	U Miami	Pallikkuth et al. (2020)
Antibody
Seroneutralization assay	Crucell/Janssen	Ockenhouse et al. (2015); Kazmin et al. (2017)	B-cell ELISpot	U Miami	Pallikkuth et al. (2020)
Ab-mediated opsonization	WRAIR	Chaudhury et al. (2016)	Ab-mediated opsonization	WRAIR	Chaudhury et al. (2017)
Ab functionality b	MGH	Suscovich et al. (2020)	Ab functionality	MGH	Unpublished
ELISA c	CEVAC, GSK, WRAIR	Ockenhouse et al. (2015); Chaudhury et al. (2016); Radin et al. (2016)	ELISA–Titer d	CEVAC, GSK, WRAIR, U Miami	Radin et al. (2016); Regules et al. (2016); Chaudhury et al. (2017)
			ELISA–Avidity e
BAMA IgG Subclass (IgG1-4) f & BLI Ab Avidity g	Duke	Seaton et al. (under revision)1	BLI Ab Avidity h	Duke	Seaton et al. (under revision) 1
			BAMA and BLI IgG Subclass (IgG 1–4) i
			Luminex j	WRAIR, U Miami	Chaudhury et al. (2017); Pallikkuth et al. (2020); Pallikkuth et al. (2020)
			B cell phenotyping	U Miami
Other
Microscopy		Ockenhouse et al. (2015)	Microscopy		Regules et al. (2016)
PCR		Ockenhouse t al. (2015)	PCR		Regules et al. (2016)

^aIncludes: T cells, peripheral T follicular helper (pTfh) cells, B cells.

^bIncludes: antibody-dependent cellular cytoxicity (ADCC), antibody-dependent complement deposition (ADCD), antibody-dependent cellular phagocytosis (ADCP), antibody dependent dendritic cell phagocytosis (ADDCP), antibody-dependent natural killer cell activation (ADNKA), antibody-dependent neutrophil phagocytosis (ADNP), Fc array, and Ig subclass.

^cIncludes: anti-circumsporozoite (CS), anti-Hepatitis B surface antigen (HBsAg), anti-full length CS and anti-NANP6 IgG titers; anti-CS IgG avidity.

^dIncludes: anti-CS, anti-full length CSP, anti-C-term, anti-NANP, and anti-HBsAg IgG titers.

^eIncludes: anti-full length CSP, anti-C-term, anti-NANP, anti-CS repeat region IgG avidity may be transferred at a later date.

^fIncludes: binding antibody multiplex assay (BAMA) full length circumsporozoite protein (CSP), NANP6, NPNA3, C-term, and Hepatitis B subclass (IgG1-4).

^gIncludes: biolayer interferometry (BLI) full length CSP, C-term, NANP6, NPNA3, and N-interface.

^hIncludes: full length CSP, NANP6, NPNA3, N-interface, C-term BLI Ab Avidity data.

ⁱIncludes: BAMA full length CSP IgG1-4, NANP6 IgG1-4, C-term IgG3, and Hepatitis B IgG3 and BLI full-length CSP subclass avidity.

^jIncludes: full-length CSP, C-term, NANP6 IgG1-4 subclass titer