TABLE 6.
Cytotoxic activity of SCZ and its metal complexes against human tumor cells and SD values.
| Compound | In vitro cytotoxicity IC50 (µg/ml) 1 /SD | |||
|---|---|---|---|---|
| Breast cell line (MCF-7) | SD | Colon cell line (CaCo-2) | SD | |
| SCZ ligand | 215.24 | ±0.67 | 97.6 | ±0.45 |
| [Cu(SCZ)2Cl]Cl | 86.2 | ±0.64 | 23.84 | ±0.33 |
| [Zn(SCZ)2]Cl2 | 111.91 | ±0.36 | 198.44 | ±0.25 |
| [Ni(SCZ)2Cl2] | 45.62 | ±0.28 | 106.87 | ±0.34 |
| [Co(SCZ)2ClOH2]Cl | 54.23 | ±0.52 | 190.1 | ±0.30 |
| [Fe(SCZ)2Cl2] | 284.25 | ±0.31 | 362.9 | ±0.41 |
1
IC50 (mg/ml): 1–10 (very strong), 11–20 (strong), 21–50 (moderate), 51–100 (weak), and above 100 (non-cytotoxic).