Table 3.
Summarize Statistics Model of Box–Behnken Design Used for Optimization of Ethosomal RP with Their Regression Equation
| Dependent Variables | R2 | Adjusted R2 | Predicted R2 | P value |
|---|---|---|---|---|
| Y1: particle size(nm) | 0.9341 | 0.9161 | 0.8692 | 0.0001 |
| Y2: ZP (mV) | 0.9032 | 0.8768 | 0.8127 | 0.0001 |
| Y3: % EE | 0.9918 | 0.9772 | 0.9070 | 0.0001 |
| Y4: % drug released over 24 hr | 0.9658 | 0.9564 | 0.9462 | 0.0001 |
| Y5: % drug permeated over 24 hr | 0.9715 | 0.9638 | 0.9532 | 0.0001 |
| Regression equation of the fitted model | ||||
| Y1= 294.86 + 74.9875A - 42.2 B - 12.5875C | ||||
| Y2= 63.0333 + 9.125A + 5.0375 B - 0.9875 C | ||||
| Y3= 94.27 + 5.805 A+ 2.835B + 0.9C- 1.5525AB - 0.6775AC - 0.7925 BC- 2.00625 A2–0.27625 B2 –0.39125 C2 | ||||
| Y4= 79.6333–7.15625A + 10.0725B + 2.99625 C | ||||
| Y5= 69.5213–7.07125A + 10.4013B + 2.895 C | ||||
Note: Data are mean values (n = 3) ± SD.
Abbreviation: EE%, entrapment efficiency percent.