Table 6.

Mean Acne Lesion Count Before and After Treatment

Lesion Count	Right Side (Conventional Tretinoin)		Left Side (Ethosomal RP Hydrogel)		P-valueb
	Mean ± SD	P-valuea	Mean ± SD	P-valuea
Non-inflammatory lesions
Baseline	9.80 ± 5.27		9.35 ± 4.99		0.529
After 2 weeks	7.79 ± 4.93	0.016	6.37 ± 3.39	0.002
After 4 weeks	6.35 ± 3.51	< 0.001	4.70 ± 2.342	0.001
After 6 weeks	6.45 ± 3.75	< 0.001	4.65 ± 2.56	< 0.001	0.008
Final % reduction	34.32 ± 0.2		46.69 ± 0.24		0.071
Inflammatory lesions
Baseline	9.3 ± 6.47		9.2 ± 5.88		0.706
After 2 weeks	7.42 ± 4.86	0.006	6.11 ± 3.59	0.007
After 4 weeks	6 ± 4.32	0.005	4.55 ± 3	0.001
After 6 weeks	6.2 ± 4.1	0.001	4.6 ± 2.81	0.001	0.083
Final % reduction	28.35 ± 0.32		39.32 ± 0.37		0.432
Total lesions
Baseline	19.1 ± 8.39		18.55 ± 8.42		0.587
After 2 weeks	15.21 ± 6.96	0.005	12.47± 4.91	0.004
After 4 weeks	12.35 ± 5.57	< 0.001	9.25 ± 3.99	0.001
After 6 weeks	12.65 ± 5.62	< 0.001	9.25 ±3.89	< 0.001	0.016
Final % reduction	28.49 ± 0.21		39.95 ± 0.24		0.179

Notes: ^aComparison vs baseline within the same treatment side. ^bComparison of the two treated sides. Significance is considered at p < 0.05.